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Divergence in Cytogenetic and Molecular Genetic Analysis Results: A Case Report of Fragile X Syndrome among Siblings

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dc.contributor.authorElias Marjanu Hikmahen_US
dc.contributor.authorMamat Norhashimahen_US
dc.contributor.authorIsmail Siti Mariamen_US
dc.contributor.authorSalmi Razaken_US
dc.contributor.authorPornprot Limpraserten_US
dc.contributor.authorWanna Sudhikaranen_US
dc.contributor.authorRavindran Ankathilen_US
dc.contributor.authorAlwi Zilfalilen_US
dc.date.accessioned2024-05-28T05:48:18Z
dc.date.available2024-05-28T05:48:18Z
dc.date.issued2010
dc.description.abstractBackground: Fragile X Syndrome (FXS) is the most prevalent inherited cause of mental retardation. The prevalence of FXS in males and females are approximately 1 in 4000 and 1 in 8000 respectively. It is caused by CGG repeat instability in the FMR1 gene, located on chromosome Xq27.3. Normal individuals have CGG repeats ranging from 5 to 53. In premutation carriers, the CGG repeats range from 60 to 200 and shall be more than 200 repeats for full mutation patients. FXS patients have variable clinical features and because of that, an accurate clinical diagnosis is always a problem. Currently, Cytogenetic, PCR and Southern Blot Techniques are widely used for diagnosis of FXS. Case Report: Here we report a pair of brothers suspected to be FXS patients with similar clinical features. However, the cytogenetic result for younger brother did not show fragile site at Xq27.3 of the X chromosome while molecular result was confirmatory for FXS. Conversely, the elder brother showed confirmatory results for Fragile X mutation in both cytogenetic and molecular analysis. Conclusion: We therefore conclude that patient 1 confirms for Fragile X mosaic and patient 2 for Fragile X full mutation. From the result, cytogenetic analysis alone cannot be dependable for the confirmatory diagnosis of FXS.en_US
dc.identifier.epage139
dc.identifier.issn1341-2051
dc.identifier.issue2
dc.identifier.spage135
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/6549
dc.identifier.volume17
dc.language.isoen_USen_US
dc.publisherJapan International Cultural Exchange Foundationen_US
dc.relation.ispartofInternational Medical Journalen_US
dc.subjectfragile X syndrome, cytogenetic analysis, southern blot, FMR1 gene and CGG repeatsen_US
dc.titleDivergence in Cytogenetic and Molecular Genetic Analysis Results: A Case Report of Fragile X Syndrome among Siblingsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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