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Chemical Composition And In Vitro Antimicrobial Properties Of Phyllanthus Columnaris Stem Bark Tannins Against Oral Pathogens

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dc.contributor.authorT. A. M. Othmanen_US
dc.contributor.authorRohazila Mohd Hanafiahen_US
dc.contributor.authorNoor Akmar Namen_US
dc.contributor.authorShahida Mohd-Saiden_US
dc.contributor.authorSiti Noor Adnalizawati Adnanen_US
dc.date.accessioned2024-05-28T03:28:04Z
dc.date.available2024-05-28T03:28:04Z
dc.date.issued2019
dc.date.submitted20/12/2019
dc.description(J Int Dent Med Res 2019; 12(3): 848-853)en_US
dc.description.abstractThe potential antimicrobial properties of tannins from Phyllanthus columnaris stem bark were evaluated against three Gram-positive cariogenic bacteria (Streptococcus salivarius ATCC 13419, Streptococcus oralis ATCC 6249 and Streptococcus mutans ATCC 25175), two obligate anaerobic Gram-negative periodontopathic bacteria (Porphyromonas gingivalis ATCC 33277, and Fusobacterium spp ATCC 25586), and five Candida spp (C. albicans ATCC 14053, C. parapsilosis ATCC 22019, C. tropicalis ATCC 750, C. krusei ATCC 6258 and C. glabrata ATCC 2001). Antimicrobial activities of tannins were determined using the disc diffusion test as well as minimum inhibitory concentration and minimum bactericidal/fungicidal concentration tests. The chemical composition of tannins was analysed by direct infuse mass spectrometry. Tannins inhibited the growth of all tested pathogens at MIC value ranging from 0.16 to 1.25 mg/mL. All tested bacteria showed similar higher level of susceptibility against tannins as the lowest MIC value was detected (0.16 mg/mL) except for S. oralis (0.63 mg/mL). However, both Gram negative anaerobes recorded the lowest MBC value at 0.32 mg/mL as compared to the Gram positive cariogenic bacteria (2.5->5.0 mg/mL). DIMS analysis of precursor ions detected four compounds present in tannins namely punicafolin, (S)-Nerolidol 3-O-[a-L-Rhamnopyranosyl-(1->4)-a-L-rhamnopyranosyl-(1->2)-[4-(4-hydroxy-3 methoxycinnamoyl)-(E)-a-L-rhamnopyranosyl-(1->6)]-b-D-glucopyranoside], ent-Epicatechin-(4alpha->8)-ent-epicatechin-(4alpha->8)-ent-epicatechin 3',3''-digallate and pavetannin C1 respectively.en_US
dc.identifier.epage853
dc.identifier.issn1309-100X
dc.identifier.issue3
dc.identifier.other1209-16
dc.identifier.spage848
dc.identifier.urichrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/viewer.html?pdfurl=http%3A%2F%2Fwww.jidmr.com%2Fjournal%2Fwp-content%2Fuploads%2F2019%2F10%2F2-D18_693_Siti_Noor_Adnalizawati_Adnan.pdf&clen=489379&chunk=true
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/4221
dc.identifier.volume12
dc.language.isoenen_US
dc.publisherEctodermal Dysplasia Group Turkeyen_US
dc.relation.ispartofJournal of International Dental and Medical Researchen_US
dc.subjectOral pathogens,en_US
dc.subjectTannins,en_US
dc.subjectAntimicrobial, .en_US
dc.subjectDIMSen_US
dc.titleChemical Composition And In Vitro Antimicrobial Properties Of Phyllanthus Columnaris Stem Bark Tannins Against Oral Pathogensen_US
dc.typeArticleen_US
dspace.entity.typePublication

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