Publication: Palm Tocotrienols Inhibit Proliferation of Murine Mammary Cancer Cells and Induce Expression of Interleukin-24 mRNA
| dc.contributor.author | Kanga Rani Selvaduray | en_US |
| dc.contributor.author | Ammu K Radhakrishnan | en_US |
| dc.contributor.author | Methil Kannan Kutty | en_US |
| dc.contributor.author | Kalanithi Nesaretnam | en_US |
| dc.date.accessioned | 2024-05-28T04:30:01Z | |
| dc.date.available | 2024-05-28T04:30:01Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | Several mechanisms have been postulated for the anticancer effects of tocotrienols. In this study, for the first time, the anticancer effect of tocotrienols is linked to increased expression of interleukin-24 (IL-24) mRNA, a cytokine reported to have antitumor effects in many cancer models. Tocotrienol isomers (α-T3, γ-T3, and δ-T3) and tocotrienol-rich fraction (TRF) inhibited the growth of the 4T1 murine mammary cancer cells (P < 0.05), with IC50 values 8.99, 4.79, 3.73, and 8.63 μg/mL, respectively. Tumor incidence and tumor load in TRF-supplemented BALB/c mice was decreased by 57.1% and 93.6% (P < 0.05), respectively. The induction of the IL-24 mRNA in the 4T1 cells by vitamin E decreased in the following order: δ-T3 > γ-T3 > TRF > α-T3 > α-T, which was similar to their antiproliferative effects. The IL-24 mRNA levels in tumor tissues of BALB/c mice supplemented with TRF increased 2-fold when compared with control mice. Increased levels of IL-24 have been associated with inhibition of tumor growth and angiogenesis. Treatment of 4T1 cells with TRF and δ-T3 significantly decreased IL-8 and vascular endothelial growth factor mRNA levels. Hence, we report that tocotrienols have potent antiangiogenic and antitumor effects that is associated with increased levels of IL-24 mRNA. | en_US |
| dc.identifier.doi | 10.1089/jir.2010.0021 | |
| dc.identifier.issn | 1079-9907 | |
| dc.identifier.issue | 12 | |
| dc.identifier.uri | https://www.liebertpub.com/doi/10.1089/jir.2010.0021 | |
| dc.identifier.uri | https://oarep.usim.edu.my/handle/123456789/5764 | |
| dc.identifier.volume | 30 | |
| dc.language | English | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Mary Ann Liebert Inc | en_US |
| dc.relation.ispartof | Journal of Interferon and Cytokine Research | en_US |
| dc.title | Palm Tocotrienols Inhibit Proliferation of Murine Mammary Cancer Cells and Induce Expression of Interleukin-24 mRNA | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication |