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Diabetes Related Deaths in a Tertiary Pediatric Referral Institution in England: The Value of Biochemical Analyses in Post-Mortem Samples

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dc.contributor.authorNur Syahrina Rahim
dc.contributor.authorEleanor McTaggart
dc.contributor.authorMarta C. Cohen
dc.date.accessioned2024-06-16T06:34:39Z
dc.date.available2024-06-16T06:34:39Z
dc.date.issued2023
dc.date.submitted2024-1-23
dc.descriptionPediatric and Developmental Pathology Volume 26, Issue 2 (Page:115-123)
dc.description.abstractObjectives: To establish the incidence of “diabetes-related death” (DRD) in children with known and unknown Diabetes Mellitus (DM) dying unexpectedly, and describe post-mortem (PM) biochemistry findings. Patients and Methods: PM reports from the previous 16-year period were reviewed. Cases of DRD were extracted. All available demographic, clinical, and autopsy data including laboratory analyses was retrieved. Results: 9/1376 (0.7%) DRD cases were identified. This was attributed to Diabetic Ketoacidosis in 7 and to Death in Bed Syndrome in 2. 4/9 cases were known diabetic and on insulin; whilst in 5/9 cases the diagnosis of DM was at PM. The mean age was 11.6 years (range 2.5–15). At PM, 4 cases were undernourished. The histology demonstrated pancreatic changes in keeping with DM in 3/9 and unremarkable pancreatic findings in 6/9. 3 cases also had autoimmune thyroiditis (1 also had myocarditis and Armanni-Ebstein nephropathy). Toxicological and biochemical analysis showed raised: β-hydroxybutyrate in 6, ketone bodies in 5 cases and raised HbA1c in 3c. Conclusion: Type 1 DM is an infrequent but yet potentially preventable cause of death in children. Our findings highlight the value of routine biochemical and toxicological analysis in all PM examinations of infants and children dying suddenly and unexpectedly.
dc.identifier.citationNur Syahrina Rahim, McTaggart, E., & Cohen, M. C. (2023). Diabetes Related Deaths in a Tertiary Pediatric Referral Institution in England: The Value of Biochemical Analyses in Post-Mortem Samples. Pediatric and Developmental Pathology, 26(2), 115–123. https://doi.org/10.1177/10935266221146045
dc.identifier.doi10.1177/10935266221146045
dc.identifier.epage9
dc.identifier.issn1093-5266
dc.identifier.issue2
dc.identifier.spage1
dc.identifier.urihttps://journals.sagepub.com/doi/abs/10.1177/10935266221146045
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/19862
dc.identifier.volume26
dc.language.isoen_US
dc.publisherSAGE
dc.relation.ispartofPediatric and Developmental Pathology
dc.relation.journalPediatric and Developmental Pathology
dc.subjectbiochemical analysis
dc.subjectdiabetic ketoacidosis
dc.subjectdead-in-bed
dc.subjecthydroxybutyrate
dc.subjectsudden death
dc.subjectType 1 diabetes
dc.titleDiabetes Related Deaths in a Tertiary Pediatric Referral Institution in England: The Value of Biochemical Analyses in Post-Mortem Samples
dc.typetext::journal::journal article::research article
dspace.entity.typePublication
oaire.citation.endPage123
oaire.citation.issue2
oaire.citation.startPage115
oaire.citation.volume26
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#

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