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Significant Risk of Life Threatening Infections in Elderly Patients With Inflammatory Bowel Disease Receiving Anti-TNF Therapy

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dc.contributor.authorAhmad Najib Bin Azmien_US
dc.contributor.authorWay-Seah Leeen_US
dc.contributor.authorRuey Terng Ngen_US
dc.contributor.authorSik-Yong Ongen_US
dc.contributor.authorSanjiv Mahadevaen_US
dc.contributor.authorKhean-Lee Gohen_US
dc.contributor.authorIda Hilmien_US
dc.date.accessioned2024-05-28T03:31:56Z
dc.date.available2024-05-28T03:31:56Z
dc.date.issued2015
dc.description.abstractINTRODUCTION: Anti tumour necrosis factor (anti-TNF) is highly effective in inflammatory bowel disease (IBD) but has been associated with a risk of infectious complications, particularly in patients with advanced age. AIMS: To determine the risk of infectious complications in our elderly patients exposed to anti-TNF therapy. METHODS: This is a retrospective study carried out in the University of Malaya Medical Centre, Kuala Lumpur where all patients diagnosed with IBD on anti-TNF were recruited. Dose and duration of anti-TNF, concomitant medications and infectious complications (non IBD related) were recorded. RESULTS: 349 patients with confirmed IBD who were actively under follow up as from January 2014-2015 were identified. Of all patients who received anti-TNF, 71 were <60 years, 3 were 60 years. There was no significant difference in the use of concomitant immunomodulators in the two age groups. Infectious complications were seen in of 9(12.7%) in the younger group and 3(100%) in the elderly group. In the young age group, only one (1.4%) died from nosocomial pneumonia following an iatrogenic pneumothorax. 2 patients developed pneumonia (successfully treated) and 6 patients developed shingles. In contrast, all three (100%) of the elderly patients had significant infectious complications; one had disseminated Tuberculosis, one died following nosocomial pneumonia and one developed multiple opportunistic infections (pneumocystis pneumonia, cryptococcal meningitis). CONCLUSIONS: Anti-TNF has to be used with extreme caution and ideally avoided in elderly patients with IBD.en_US
dc.identifier.citationAhmad Najib Azmi, Way-Seah Lee, Ruey Terng Ng, Sik-Yong Ong, Sanjiv Mahadeva, Khean-Lee Goh, Ida Hilmi, Significant Risk of Life Threatening Infections in Elderly Patients With Inflammatory Bowel Disease Receiving Anti-TNF Therapy, Clinical Gastroenterology and Hepatology, Volume 13, Issue 7, 2015, Pages 1385-1386, ISSN 1542-3565, https://doi.org/10.1016/j.cgh.2015.04.042.en_US
dc.identifier.doi10.1016/j.cgh.2015.04.042
dc.identifier.epage1386
dc.identifier.issn1542-3565
dc.identifier.issue7
dc.identifier.other833-19
dc.identifier.spage1385
dc.identifier.urihttps://www.cghjournal.org/article/S1542-3565(15)00501-7/fulltext#relatedArticles
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S1542356515005017
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/4604
dc.identifier.volume13
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinical Gastroenterology and Hepatologyen_US
dc.titleSignificant Risk of Life Threatening Infections in Elderly Patients With Inflammatory Bowel Disease Receiving Anti-TNF Therapyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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