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Hepatitis C and kidney disease: An overview and approach to management

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dc.contributor.authorAzmi, ANen_US
dc.contributor.authorTan, SSen_US
dc.contributor.authorMohamed, Ren_US
dc.date.accessioned2024-05-29T02:50:19Z
dc.date.available2024-05-29T02:50:19Z
dc.date.issued2015
dc.description.abstractHepatitis C infection and chronic kidney disease are major health burden worldwide. Hepatitis C infection is associated with a wide range of extra-hepatic manifestations in various organs including the kidneys. A strong association between hepatitis C and chronic kidney disease has come to light. Hemodialysis in supporting the end stage renal disease patients unfortunately carries a risk for hepatitis C infection. Despite much improvement in the care of this group of patients, the prevalence of hepatitis C infection in hemodialysis patients is still higher than the general population. Hepatitis C infection has a negative effect on the survival of hemodialysis and renal transplant patients. Treatment of hepatitis C in end stage renal disease patients using conventional or pegylated interferon with or without ribavirin remains a clinical challenge with low response rate, high dropout rate due to poor tolerability and many unmet needs. The approval of new direct acting antiviral agents for hepatitis C may dramatically change the treatment approach in hepatitis C infected patients with mild to moderate renal impairment. However it remains to be confirmed if the newer Hepatitis C therapies are safe in individuals with severe renal impairment. This review article discusses the relationship between hepatitis C and chronic kidney disease, describe the various types of renal diseases associated with hepatitis C and the newer as well as the existing treatments for hepatitis C in the context of this subpopulation of hepatitis C patients.
dc.identifier.doi10.4254/wjh.v7.i1.78
dc.identifier.epage92
dc.identifier.issn1948-5182
dc.identifier.issue1
dc.identifier.scopusWOS:000439184000009
dc.identifier.spage78
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11038
dc.identifier.volume7
dc.languageEnglish
dc.language.isoen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal Of Hepatology
dc.sourceWeb Of Science (ISI)
dc.subjectChronic hepatitis Cen_US
dc.subjectKidney diseaseen_US
dc.subjectManagementen_US
dc.titleHepatitis C and kidney disease: An overview and approach to management
dc.typeArticleen_US
dspace.entity.typePublication

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