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Disruption of white matter integrity and its relationship with cognitive function in non-severe traumatic brain injury

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dc.contributor.authorAimi Nadhiah Abdullahen_US
dc.contributor.authorAsma Hayati Ahmaden_US
dc.contributor.authorRahimah Zakariaen_US
dc.contributor.authorSofina Tamamen_US
dc.contributor.authorAini Ismafairus Abd Hamiden_US
dc.contributor.authorWen Jia Chaien_US
dc.contributor.authorHazim Omaren_US
dc.contributor.authorMuhammad Riddha Abdul Rahmanen_US
dc.contributor.authorDiana Noma Fitzrolen_US
dc.contributor.authorZamzuri Idrisen_US
dc.contributor.authorAbdul Rahman Izaini Ghanien_US
dc.contributor.authorWan Nor Azlen Wan Mohamaden_US
dc.contributor.authorFaiz Mustafaren_US
dc.contributor.authorMuhammad Hafiz Hanafien_US
dc.contributor.authorMohamed Faruque Rezaen_US
dc.contributor.authorHafidah Umaren_US
dc.contributor.authorMohd Faizal Mohd Zulkiflyen_US
dc.contributor.authorSong Yee Angen_US
dc.contributor.authorZaitun Zakariaen_US
dc.contributor.authorKamarul Imran Musaen_US
dc.date.accessioned2024-05-28T04:30:38Z
dc.date.available2024-05-28T04:30:38Z
dc.date.issued2022
dc.date.submitted2022-10-25
dc.descriptionFront. Neurol., 11 October 2022 Sec. Neurotraumaen_US
dc.description.abstractBackground: Impairment in cognitive function is a recognized outcome of traumatic brain injury (TBI). However, the degree of impairment has variable relationship with TBI severity and time post injury. The underlying pathology is often due to diffuse axonal injury that has been found even in mild TBI. In this study, we examine the state of white matter putative connectivity in patients with non-severe TBI in the subacute phase, i.e., within 10 weeks of injury and determine its relationship with neuropsychological scores. Methods: We conducted a case-control prospective study involving 11 male adult patients with non-severe TBI and an age-matched control group of 11 adult male volunteers. Diffusion MRI scanning and neuropsychological tests were administered within 10 weeks post injury. The difference in fractional anisotropy (FA) values between the patient and control groups was examined using tract-based spatial statistics. The FA values that were significantly different between patients and controls were then correlated with neuropsychological tests in the patient group. Results: Several clusters with peak voxels of significant FA reductions (p < 0.05) in the white matter skeleton were seen in patients compared to the control group. These clusters were located in the superior fronto-occipital fasciculus, superior longitudinal fasciculus, uncinate fasciculus, and cingulum, as well as white matter fibers in the area of genu of corpus callosum, anterior corona radiata, superior corona radiata, anterior thalamic radiation and part of inferior frontal gyrus. Mean global FA magnitude correlated significantly with MAVLT immediate recall scores while matrix reasoning scores correlated positively with FA values in the area of right superior fronto-occipital fasciculus and left anterior corona radiata. Conclusion: The non-severe TBI patients had abnormally reduced FA values in multiple regions compared to controls that correlated with several measures of executive function during the sub-acute phase of TBI.en_US
dc.identifier.citationAbdullah AN, Ahmad AH, Zakaria R, Tamam S, Abd Hamid AI, Chai WJ, Omar H, Abdul Rahman MR, Fitzrol DN, Idris Z, Ghani ARI, Wan Mohamad WNA, Mustafar F, Hanafi MH, Reza MF, Umar H, Mohd Zulkifly MF, Ang SY, Zakaria Z, Musa KI, Othman A, Embong Z, Sapiai NA, Kandasamy R, Ibrahim H, Abdullah MZ, Amaruchkul K, Valdes-Sosa PA, Bringas Vega ML, Biswal B, Songsiri J, Yaacob HS, Sumari P, Noh NA, Azman A, Jamir Singh PS and Abdullah JM (2022) Disruption of white matter integrity and its relationship with cognitive function in non-severe traumatic brain injury. Front. Neurol. 13:1011304. doi: 10.3389/fneur.2022.1011304en_US
dc.identifier.doi10.3389/fneur.2022.1011304
dc.identifier.epage12
dc.identifier.issn1664-2295
dc.identifier.issue4
dc.identifier.other823-32
dc.identifier.spage1
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fneur.2022.1011304/full
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/5784
dc.identifier.volume13
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.relation.ispartofFrontiers in Neurologyen_US
dc.subjecttraumatic brain injury, diffusion MRI, fractional anisotropy, neuropsychological test, tract-based spatial statisticen_US
dc.titleDisruption of white matter integrity and its relationship with cognitive function in non-severe traumatic brain injuryen_US
dc.typeArticleen_US
dspace.entity.typePublication

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