Repository logo
  • English
  • Català
  • Čeština
  • Deutsch
  • Español
  • Français
  • Gàidhlig
  • Italiano
  • Latviešu
  • Magyar
  • Nederlands
  • Polski
  • Português
  • Português do Brasil
  • Srpski (lat)
  • Suomi
  • Svenska
  • Türkçe
  • Tiếng Việt
  • Қазақ
  • বাংলা
  • हिंदी
  • Ελληνικά
  • Српски
  • Yкраї́нська
  • Log In
    New user? Click here to register.Have you forgotten your password?
Repository logo
    Communities & Collections
    Research Outputs
    Fundings & Projects
    People
    Statistics
  • English
  • Català
  • Čeština
  • Deutsch
  • Español
  • Français
  • Gàidhlig
  • Italiano
  • Latviešu
  • Magyar
  • Nederlands
  • Polski
  • Português
  • Português do Brasil
  • Srpski (lat)
  • Suomi
  • Svenska
  • Türkçe
  • Tiếng Việt
  • Қазақ
  • বাংলা
  • हिंदी
  • Ελληνικά
  • Српски
  • Yкраї́нська
  • Log In
    New user? Click here to register.Have you forgotten your password?
  1. Home
  2. Staff Publications
  3. Other Publications
  4. Anthelmintic Activity of Goat's Milk: Transmission Electron Micrographic Evidence
 
  • Details
Options

Anthelmintic Activity of Goat's Milk: Transmission Electron Micrographic Evidence

Journal
Scholars International Journal of Chemistry and Material Sciences
Date Issued
2018
Author(s)
Omaima Adil Najm
Faizul Helmi Addnan 
Universiti Sains Islam Malaysia 
Mohamed Adel Elkadi
Wan Omar Abdullah
Nur Fariha Mohd Manzor 
Universiti Sains Islam Malaysia 
Noor Amiza Zainal Abidin
Fadlul Azim Fauzi Mansur 
Universiti Sains Islam Malaysia 
DOI
10.36348/sijcms.2018.v01i03.001
Abstract
Using the canine hookworm Ancylostoma caninum as model we aimed to investigate the anthelmintic activity of goat's milk in vitro by describing in detail the nature of damage taking place cross sectionally in the worm cuticle after exposure to goat's milk through careful observation by transmission electron microscope (TEM). Adult worms were obtained from routine culling of unwanted dogs from Selayang Municipal Council (MPS) animal detention center, Rawang, Malaysia. Fresh raw goat's milk was used. Worms were cut into 1mm3 slices, fixed in 4% glutaraldehyde, washed with 0.1sodium cacodylate buffer, post fixed in 1% osmium tetroxide, washed again in 1%sodium cacodylate buffer, dehydrated in acetone, embedded in resin, polymerized, ultrathin cross section cut and stained with uranyl acetate before being viewed under transmission electron microscope. Goat's milk resulted in worm cuticular damage in the form of irregularity and significant thinning similarly seen with cysteine proteinases mediated damage. Internal hypodermic changes were also observed in the form of mitochondrial degeneration which appeared as large vacuoles similarly seen in albendazole affected worms. Understanding anthelmintic mechanism through transmission electron micrography has provided critical information in developing novel therapies from natural products. It also provides basis for the consumption of goat's milk as functional food for parasitic worm control.
Subjects

milk, goat's milk, An...

File(s)
Loading...
Thumbnail Image
Name

Anthelmintic Activity of Goat's Milk Transmission Electron Micrographic Evidence.pdf

Size

599.29 KB

Format

Adobe PDF

Checksum

(MD5):35b99313915520e44de9c7b5e2a63ef5

Welcome to SRP

"A platform where you can access full-text research
papers, journal articles, conference papers, book
chapters, and theses by USIM researchers and students.”

Contact:
  • ddms@usim.edu.my
  • 06-798 6206 / 6221
  • USIM Library
Follow Us:
READ MORE Copyright © 2024 Universiti Sains Islam Malaysia