Publication:
Anti-urolithiatic terpenoid compound from Plantago major Linn. (Ekor Anjing)

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dc.citedby6
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsForest Research Institute of Malaysia
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.authorSharifa A.A.en_US
dc.contributor.authorJamilah Jamaludinen_US
dc.contributor.authorKiong L.S.en_US
dc.contributor.authorChia L.A.en_US
dc.contributor.authorOsman K.en_US
dc.date.accessioned2024-05-29T02:00:59Z
dc.date.available2024-05-29T02:00:59Z
dc.date.issued2012
dc.description.abstractThe aim of this study was to determine the inhibition effects of the terpenoid of Plantago major on calcium oxalate crystals in vitro and to compare the effects of Plantago major with clinically used drugs like zyloric and potassium citrate for the treatment of urinary stone. Modified Schneider slide gel method was used for in vitro study and crystals formed were measured by Image Analyser System (Leica) after 24 h of treatment. The active compound in the methanol extract of Plantago major was isolated by bioassay - guided fractionation & isolation method. Dimethylsulphoxide (DMSO) was used as the negative control and zyloric and potassium citrate were used as positive controls. The results showed that crude methanol extract of Plantago major contained the active compound terpenoid. Terpenoid, zyloric and potassium citrate at concentrations in the range of (100 ?g/mL - 250 ?g/mL) signifcantly inhibited the area of crystal formation in comparison to the negative control after 24 h (p<0.001). The Zyloric and terpenoid of Plantago major in the concentrations of (100 ?g/mL-250 ?g/mL) inhibited the sizes of crystals signifcantly (p<0.05). Potassium citrate was more effective, than terpenoid of Plantago major in inhibiting the size of crystals at two concentrations i.e. 100 ?g/mL and 150 ?g/mL respectively (p<0.05). However the IC 50 values for terpenoid of Plantago major, potassium citrate and zyloric were 250 ?g/mL, 300 ?g/mL and 550 ?g/mL, respectively. The inhibition effect of the terpenoid of Plantago major extract on crystal size was much better than Zyloric and potassium citrate.en_US
dc.description.natureFinalen_US
dc.identifier.epage39
dc.identifier.issn1266039
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84055193554
dc.identifier.spage33
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84055193554&partnerID=40&md5=a2762d6c28f40aaf1fabae23c48abaf5
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10147
dc.identifier.volume41
dc.languageEnglish
dc.language.isoen_USen_US
dc.relation.ispartofSains Malaysiana
dc.sourceScopus
dc.subjectCalcium oxalate crystalsen_US
dc.subjectInhibition effectsen_US
dc.subjectPlantago majoren_US
dc.subjectTerpenoiden_US
dc.titleAnti-urolithiatic terpenoid compound from Plantago major Linn. (Ekor Anjing)en_US
dc.title.alternativeSains Malays.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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