Publication:
Fabrication of fucoxanthin-loaded microsphere (F-LM) by two steps double-emulsion solvent evaporation method and characterization of fucoxanthin before and after microencapsulation

Simple item page
dc.Chemicals/CASfucoxanthin, 3351-86-8; lactic acid, 113-21-3, 50-21-5; polyglycolic acid, 26009-03-0, 26124-68-5, 26202-08-4; xanthophyll, 127-40-2, 52842-48-5; Drug Carriers; Emulsions; fucoxanthin; Lactic Acid; Polyglycolic Acid; polylactic acid-polyglycolic acid copolymer; Solvents; Surface-Active Agents; Xanthophylls
dc.FundingDetailsInternational Islamic University Malaysia International Islamic University Malaysia
dc.FundingDetailsThis research was supported by the MIRGS13-01-001-002 and RMGS-09-05 grants from International Islamic University Malaysia (IIUM)
dc.citedby7
dc.contributor.affiliationsFaculty of Dentistry
dc.contributor.affiliationsInternational Islamic University Malaysia (IIUM)
dc.contributor.affiliationsSurya University
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsRiau University
dc.contributor.affiliationsHokkaido University
dc.contributor.authorNoviendri D.en_US
dc.contributor.authorJaswir I.en_US
dc.contributor.authorTaher M.en_US
dc.contributor.authorMohamed F.en_US
dc.contributor.authorSalleh H.M.en_US
dc.contributor.authorNoorbatcha I.A.en_US
dc.contributor.authorOctavianti F.en_US
dc.contributor.authorLestari W.en_US
dc.contributor.authorHendri R.en_US
dc.contributor.authorAhmad H.en_US
dc.contributor.authorMiyashita K.en_US
dc.contributor.authorAbdullah A.en_US
dc.date.accessioned2024-05-28T08:33:56Z
dc.date.available2024-05-28T08:33:56Z
dc.date.issued2016
dc.description.abstractMicroencapsulation is a promising approach in drug delivery to protect the drug from degradation and allow controlled release of the drug in the body. Fucoxanthin-loaded microsphere (F-LM) was fabricated by two step w/o/w double emulsion solvent evaporation method with poly (L-lactic-coglycolic acid) (PLGA) as carrier. The effect of four types of surfactants (PVA, Tween-20, Span-20 and SDS), homogenization speed, and concentration of PLGA polymer and surfactant (PVA), respectively, on particle size and morphology of F-LM were investigated. Among the surfactants tested, PVA showed the best results with smallest particle size (9.18 ?m) and a smooth spherical surface. Increasing the homogenization speed resulted in a smaller mean F-LM particle size [d (0.50)] from 17.12 to 9.18 ?m. Best particle size results and good morphology were attained at homogenization speed of 20 500 rpm. Meanwhile, increased PLGA concentration from 1.5 to 11.0 (% w/v) resulted in increased F-LM particle size. The mean particle size [d (0.5)] of F-LM increased from 3.93 to 11.88 ?m. At 6.0 (% w/v) PLGA, F-LM showed the best structure and external morphology. Finally, increasing PVA concentration from 0.5 to 3.5 (% w/v) resulted in decreased particle size from 9.18 to 4.86 ?m. Fucoxanthin characterization before and after microencapsulation was carried out to assess the success of the microencapsulation procedure. Thermo gravimetry analysis (TGA), glass transition (Tg) temperature of F-LM and fucoxanthin measured using DSC, ATR-FTIR and XRD indicated that fucoxanthin was successfully encapsulated into the PLGA matrix, while maintaining the structural and chemical integrity of fucoxanthin. � 2016 by Japan Oil Chemists� Society.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.5650/jos.ess16018
dc.identifier.epage653
dc.identifier.issn13458957
dc.identifier.issue8
dc.identifier.pmid27430384
dc.identifier.scopus2-s2.0-84982868455
dc.identifier.spage641
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84982868455&doi=10.5650%2fjos.ess16018&partnerID=40&md5=a97a1d2f245d38bb650162b02cc7335b
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9074
dc.identifier.volume65
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherJapan Oil Chemists Societyen_US
dc.relation.ispartofOpen Accessen_US
dc.relation.ispartofJournal of Oleo Science
dc.sourceScopus
dc.subjectFucoxanthinen_US
dc.subjectMicroencapsulationen_US
dc.subjectMicrosphereen_US
dc.subjectSolvent evaporation methoden_US
dc.subjectW/o/w double emulsionen_US
dc.titleFabrication of fucoxanthin-loaded microsphere (F-LM) by two steps double-emulsion solvent evaporation method and characterization of fucoxanthin before and after microencapsulationen_US
dc.title.alternativeJ. Oleo Sci.en_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Fabrication of fucoxanthin-loaded microsphere (F-LM) by two steps double-emulsion solvent.pdf
Size:
2.12 MB
Format:
Adobe Portable Document Format
Download

Collections

Scopus