Publication:
Protective role of eurycoma longifolia jack root extract against high-fat diet induced testicular damage in sprague-dawley rats

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dc.Chemicals/CAStestosterone, 58-22-0
dc.FundingDetailsInternational Islamic University Malaysia,�IIUM: :18-030-0030
dc.FundingDetailsThe authors would like to thank International Islamic University Malaysia for funding this project under P RIGS grant number:18-030-0030.
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsAl-Hikmah University College
dc.contributor.affiliationsInternational Islamic University Malaysia (IIUM)
dc.contributor.affiliationsAl Jouf University
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorAl-Ani I.M.en_US
dc.contributor.authorKu-Zaifah N.en_US
dc.contributor.authorAl-Joufi F.A.en_US
dc.contributor.authorMokhtar R.H.en_US
dc.contributor.authorTalib N.A.en_US
dc.contributor.authorFaisal G.G.en_US
dc.date.accessioned2024-05-28T08:25:13Z
dc.date.available2024-05-28T08:25:13Z
dc.date.issued2019
dc.description.abstractObjective: The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether Eurycoma Longifolia (EL) is able to ameliorate these effects. Methods: Twenty-four male Sprague-Dawley (SD) rats were divided into four groups each containing 6 rats. Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15 mg/ kg) dissolved in distilled water, group HFD was given only high-fat-diet and group HFDEL was given high-fat-diet and EL extracts (15 mg/kg). EL was administered orally for 12 weeks. The animal's testosterone level was measured at week 0, 6 and 12. The rats were sacrificed at the end of 12th weeks and the testes samples were processed for histological examination Results: The testosterone level was significantly increased (p < 0.05) in the in the treated rats with EL (NDEL and HFDEL) compared with ND and HFD groups. Treatment with HFD revealed a marked degeneration of the seminiferous tubule epithelium and disruption of interstitial cells of the testis thereby interfering with spermatogenesis. Treatment of HFD rats with El reduced the adverse effects of HFD and improved the morphological structure of the seminiferous tubules. Conclusion: These findings revealed that EL has ameliorative effects against the testicular damage caused by high-fat-diet.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.5530/pj.2019.11.129
dc.identifier.epage811
dc.identifier.issn9753575
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85071244009
dc.identifier.spage808
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071244009&doi=10.5530%2fpj.2019.11.129&partnerID=40&md5=31bc8a050eda490d00529ded69e5f250
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8622
dc.identifier.volume11
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherEManuscript Technologiesen_US
dc.relation.ispartofOpen Accessen_US
dc.relation.ispartofPharmacognosy Journal
dc.sourceScopus
dc.subjectEurycoma longifoliaen_US
dc.subjectHigh-fat-dieten_US
dc.subjectSeminiferous tubulesTongkat Alien_US
dc.subjectTestisen_US
dc.subjectTestosteroneen_US
dc.subjectSprague Dawley raten_US
dc.titleProtective role of eurycoma longifolia jack root extract against high-fat diet induced testicular damage in sprague-dawley ratsen_US
dc.title.alternativePharmacogn J.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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