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Molecular epidemiology of blastocystosis in Malaysia: Does seasonal variation play an important role in determining the distribution and risk factors of Blastocystis subtype infections in the Aboriginal community?

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dc.Chemicals/CASDNA, Protozoan
dc.MolecularSequenceNumbersGENBANK: KX351975:KX351997
dc.citedby6
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM) Medical Centre
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Tunku Abdul Rahman (UTAR)
dc.contributor.affiliationsUniversiti Teknologi MARA (UiTM)
dc.contributor.affiliationsKolej Universiti INSANIAH
dc.contributor.authorNoradilah S.A.en_US
dc.contributor.authorMoktar N.en_US
dc.contributor.authorAnuar T.S.en_US
dc.contributor.authorLee I.L.en_US
dc.contributor.authorSalleh F.M.en_US
dc.contributor.authorManap S.N.A.A.en_US
dc.contributor.authorMohtar N.S.H.M.en_US
dc.contributor.authorAzrul S.M.en_US
dc.contributor.authorAbdullah W.O.en_US
dc.contributor.authorNordin A.en_US
dc.contributor.authorAbdullah S.R.en_US
dc.date.accessioned2024-05-28T08:26:25Z
dc.date.available2024-05-28T08:26:25Z
dc.date.issued2017
dc.description.abstractBackground: Alternating wet and dry seasons may play an important role in the acquisition and distribution of Blastocystis subtype infection in the tropics. This cross-sectional study was therefore conducted to provide the prevalence of Blastocystis and to determine the potential risk factors associated with each subtype during the wet and dry seasons in the Aboriginal community, Pahang, Malaysia. Methods: A total of 473 faecal samples were collected: 256 (54.1%) and 217 (45.9%) samples were obtained during the wet (October-November 2014) and the dry season (June 2015), respectively. All fresh faecal samples were subjected to molecular analysis for subtype and allele identification. Results: Of the 473 samples, 42.6% and 37.8% were positive for Blastocystis ST1, ST2, ST3 and ST4 during wet and dry seasons, respectively. Prevalence of Blastocystis ST1 was significantly higher during the wet season compared to the dry season (Z = 2.146, P < 0.05). Analysis of the association of each Blastocystis subtype with socioeconomic characteristics showed the presence of other family members infected with Blastocystis ST3 and the use of stored river water for domestic activities were the significant risk factors for Blastocystis ST3 infections during both seasons. Untreated water supply and low monthly household income (less or equal to RM 500) were the other significant risk factors for Blastocystis ST3 infections during wet and dry season, respectively. The presence of other family members with Blastocystis ST1 and ST2 was the only significant risk factor associated with ST1 and ST2 infections during both seasons. We hypothesise that transmission of Blastocystis ST1, ST2 and ST3 occurred from person to person during both seasons. The waterborne transmission was also identified as a mode of transmission of Blastocystis ST3. Conclusion: The significant risk factors identified in this study were important in the dynamic transmission of Blastocystis infections during both seasons. Provision of treated water supply and health education are affirmative actions to be taken to control Blastocystis infections in this community. 2017 The Author(s).en_US
dc.description.natureFinal
dc.identifier.ArtNo360
dc.identifier.citationNoradilah, S.A., Moktar, N., Anuar, T.S. et al. Molecular epidemiology of blastocystosis in Malaysia: does seasonal variation play an important role in determining the distribution and risk factors of Blastocystis subtype infections in the Aboriginal community?. Parasites Vectors 10, 360 (2017). https://doi.org/10.1186/s13071-017-2294-2en_US
dc.identifier.doi10.1186/s13071-017-2294-2
dc.identifier.issn1756-3305
dc.identifier.issue1
dc.identifier.pmid28760145
dc.identifier.scopus2-s2.0-85026503521
dc.identifier.scopusWOS:000407052100001
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85026503521&doi=10.1186%2fs13071-017-2294-2&partnerID=40&md5=5ca4f115d6e6034f41ee1765fe61061c
dc.identifier.urihttps://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-017-2294-2
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8730
dc.identifier.volume10
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofOpen Accessen_US
dc.sourceScopus
dc.subjectBlastocystisen_US
dc.subjectPerson to person transmissionen_US
dc.subjectRisk factorsen_US
dc.subjectSeasonal variationsen_US
dc.subjectWater-borne transmissionen_US
dc.titleMolecular epidemiology of blastocystosis in Malaysia: Does seasonal variation play an important role in determining the distribution and risk factors of Blastocystis subtype infections in the Aboriginal community?en_US
dc.title.alternativeParasites Vectorsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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