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Synthesis, DFT, electrochemical, biological and DNA-interaction studies of a novel copper(II) complex of salicylic acid and N-tosyl substituted benzimidazole

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dc.contributor.authorRashid, Nen_US
dc.contributor.authorKiran, Aen_US
dc.contributor.authorAhmad, Ien_US
dc.contributor.authorAshraf, Zen_US
dc.contributor.authorYamin, BMen_US
dc.contributor.authorRafiq, Men_US
dc.date.accessioned2024-05-29T02:55:59Z
dc.date.available2024-05-29T02:55:59Z
dc.date.issued2020
dc.description.abstractSulfonylbenzimidazoles and their copper complexes have tremendous applications in drug development. In the present work, bis(2-hydroxylbenzoato-kappa O-2,O ')bis(2-methyl-1-(toluene-4-sulfonyl)-1H-benzimidazole) copper(II) complex [Cu(L-1)(L-2)] has been synthesized and structurally characterized by Fourier-transformed infrared spectroscopy (FTIR) and single-crystal X-ray diffraction (XRD). The complex formed a distorted octahedral geometry with the benzimidazole ligands occupying the axial position and the hydroxylbenzoato ligands in the equatorial positions. The latter ligands coordinated in an isobidentate manner with a Cu-O-deprotenated bond length of 1.955(18) angstrom and a long range Cu-O-carbonyl of 2.574(2) angstrom. An excellent correlation was found between bond lengths and bond angles obtained experimentally from single-crystal XRD analysis and that obtained from density functional theory. Electrochemical behavior of [Cu(L-1)(L-2)] has been probed by cyclic voltammetry (CV). CV studies revealed that it undergoes one-electron reduction followed by one-electron oxidation process. In vitro tyrosinase inhibitory activity of the complex was evaluated and it was observed that it exhibited good inhibitory potential with IC50 value 56.8 +/- 11.4 mu M. Complex-DNA-interaction studies were performed by CV, electronic and florescence spectroscopic titrations and it has been inferred that the [Cu(L-1)(L-2)] binds with DNA through intercalation and the value of binding constant was 3.6 x 10(4) M-1.
dc.identifier.doi10.1080/00958972.2020.1714602
dc.identifier.epage66
dc.identifier.isbn1029-0389
dc.identifier.issn0095-8972
dc.identifier.issue1
dc.identifier.scopusWOS:000508106300001
dc.identifier.spage52
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11561
dc.identifier.volume73
dc.languageEnglish
dc.language.isoen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Coordination Chemistry
dc.subjectBenzimidazoleen_US
dc.subjectelectrochemicalen_US
dc.subjectdensity functional theoryen_US
dc.subjectDNA-interactionen_US
dc.subjectcopper complexen_US
dc.titleSynthesis, DFT, electrochemical, biological and DNA-interaction studies of a novel copper(II) complex of salicylic acid and N-tosyl substituted benzimidazole
dc.typeArticleen_US
dspace.entity.typePublication

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