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An Unusual Presentation Of Midline Lethal Granuloma

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dc.contributor.authorEin Wan Chinen_US
dc.contributor.authorJeyasakthy Saniasiayaen_US
dc.contributor.authorShahrul Hitamen_US
dc.contributor.authorEyzawiah Hassanen_US
dc.contributor.authorNgan Kah Waien_US
dc.date.accessioned2024-05-29T02:28:49Z
dc.date.available2024-05-29T02:28:49Z
dc.date.issued2023
dc.date.submitted2024-2-6
dc.description.abstractExtranodal natural killer T-cell lymphoma, nasal type (ENKTCL), is a rare form of non-Hodgkin lymphoma that is strongly related to Epstein-Barr Virus (EBV) infection and commonly presents as “midline lethal granuloma.” Herein, we report a middle-aged lady who presented with a two-week history of fever, sore throat and constitutional symptoms. Intraoral examination revealed a lacerated soft palate with an ulcerated uvula. A diagnosis of ENKTCL was confirmed through deep biopsies under general anaesthesia supplemented with a positive serum EBV genome. Unfortunately, she succumbed due to disease progression with left frontal brain metastasis with concurrent pulmonary tuberculosis before treatment was completed. The recommended treatment is multimodality with L-asparaginase-containing regimes chemotherapy in an advanced stage, relapsed, or refractory ENKTCL for better outcomes. The quantification of circulating plasma EBV deoxyribonucleic acid (DNA) is helpful as the baseline of tumour load and a biomarker for monitoring treatment response and prognostication. We advocate repeated and deeper core tissue biopsies.en_US
dc.identifier.citationEin Wan Chin, Jeyasakthy Saniasiaya, Shahrul Hitam, Hassan, E., & Ngan Kah Wai. (2023). An Unusual Presentation of Midline Lethal Granuloma. Indian Journal of Otolaryngology and Head & Neck Surgery. https://doi.org/10.1007/s12070-023-04466-xen_US
dc.identifier.doi10.1007/s12070-023-04466-x
dc.identifier.epage2140
dc.identifier.issn2231-3796
dc.identifier.spage2137
dc.identifier.urihttps://link.springer.com/article/10.1007/s12070-023-04466-x
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85184888608&origin=resultslist&sort=plf-f&src=s&sid=a49b967dde61478abed853814bc9e606&sot=b&sdt=b&s=TITLE-ABS-KEY%28An+Unusual+Presentation+of+Midline+Lethal+Granuloma%29&sl=132&sessionSearchId=a49b967dde61478abed853814bc9e606&relpos=0
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10783
dc.language.isoen_USen_US
dc.publisherSpringerLinken_US
dc.relation.ispartofIndian Journal of Otolaryngology and Head and Neck Surgeryen_US
dc.subjectGranuloma, Lethal midline mass, Lymphoma, non Hodgkin, Extranodal NK-T-cell lymphoma, Epsteinbarr virus infections, Metastasisen_US
dc.titleAn Unusual Presentation Of Midline Lethal Granulomaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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