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Date palm fruit (var. Ajwa) promotes proliferation of human bone marrow mesenchymal stem cells: potential natural booster for endogenous stem cells growth

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dc.contributor.authorMasniza, M. L.en_US
dc.contributor.authorZetty Nadia Mohd Zainen_US
dc.contributor.authorNur Syahrina Rahimen_US
dc.contributor.authorHayati, A. R.en_US
dc.contributor.authorWirda, A. A. Asralen_US
dc.contributor.authorFauzi, M. Fadlul Azimen_US
dc.contributor.authorFariha, M. M. Nuren_US
dc.date.accessioned2024-05-29T03:25:29Z
dc.date.available2024-05-29T03:25:29Z
dc.date.issued2020
dc.descriptionFruits, The International Journal of Tropical and Subtropical Horticulture Fruits 75 (4) 161-169 ISSN 0248-1294 print and 1625-967X onlineen_US
dc.description.abstractObjective - Maintenance of bone marrow derived mesenchymal stem cells (BMMSC) numbers is important to preserve the balance required for normal tissue regeneration. 'Ajwa' date palm fruit, a popular Middle Eastern food, is known for its superior nutrition and medicinal properties. However, the direct effect of 'Ajwa' dates on stem cell biology remains unclean This study aims to investigate the potential effect of 'Ajwa' date palm fruit on BMMSC proliferation. Materials and methods - BMMSC were treated with different concentrations of aqueous extract of Ajwa' date palm fruit (mg mL(-1)). Proliferation, morphology, surface markers and gene expression of BMMSC were evaluated after the treatment. Results and discussion - 'Ajwa' date palm fruit significantly enhanced BMMSC proliferation and retained the sternness of BMMSC. Quantitative gene expression analysis demonstrated significant increase of proliferation related genes; beta-Catenin, C-Myc and HGF and lower expression of apoptotic genes; BAX and Caspase-3 and senescence-related gene, p21. Conclusion - These findings suggest the potential effect of 'Ajwa' date palm fruit as stem cell nutrition in the preservation of endogenous BMMSC for tissue regeneration.en_US
dc.identifier.citationMasniza, M.L. & Nadia, M.Z. & Rahim, Nur & Hayati, A.R. & Asnawi, Asral & Mansur, Fadlul & Fariha, Nur. (2020). Date palm fruit (var. Ajwa) promotes proliferation of human bone marrow mesenchymal stem cells: potential natural booster for endogenous stem cells growth. Fruits. 75. 161-169. 10.17660/th2020/75.4.3.en_US
dc.identifier.doi10.17660/th2020/75.4.3
dc.identifier.epage169
dc.identifier.issn0248-1294
dc.identifier.issn1625-967X online
dc.identifier.issue4
dc.identifier.scopusWOS:000579370300003
dc.identifier.spage161
dc.identifier.urihttps://www.pubhort.org/fruits/75/4/3/index.htm
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85090893339&doi=10.17660%2fth2020%2f75.4.3&partnerID=40&md5=eba141abe804e52b5864d629640a23b6
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11973
dc.identifier.volume75
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherInt Soc Horticultural Science-Ishsen_US
dc.relation.ispartofThe International Journal of Tropical & Subtropical Horticultureen_US
dc.subjectPhoenix dactylifera L.en_US
dc.subjectgene expressionen_US
dc.subjectnutritionen_US
dc.subjectstem cell growthen_US
dc.titleDate palm fruit (var. Ajwa) promotes proliferation of human bone marrow mesenchymal stem cells: potential natural booster for endogenous stem cells growthen_US
dc.typeArticleen_US
dspace.entity.typePublication

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