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Carbapenem-resistant enterobactericeae: Clinico-epidemiological perspective

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dc.citedby2
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsAmpang Hospital Selangor
dc.contributor.affiliationsInstitute of Medical Research
dc.contributor.authorMohamed N.A.en_US
dc.contributor.authorSaid H.M.en_US
dc.contributor.authorHussin H.en_US
dc.contributor.authorAbdul Rahman N.en_US
dc.contributor.authorHashim R.en_US
dc.date.accessioned2024-05-28T08:35:44Z
dc.date.available2024-05-28T08:35:44Z
dc.date.issued2018
dc.description.abstract?Since its first discovery in 1996, Carbapenem-resistant Enterobactericeae (CRE) has been increasingly reported as a cause of infections particularly in immuno-compromised patients. With limited treatment options, these multidrug-resistant organisms are associated with high mortality rates and are now recognized as an important cause of health-care associated infections. This study aimed to determine the prevalence of CRE at a 500-bedded tertiary hospital in Selangor, Malaysia. This study identified and analyzed CRE culture results from January 2015 to December 2016. The isolates were identified by conventional and Vitek 2� methods. Susceptibility tests were done by disk diffusion technique and confirmed by E-test. Polymerase chain reaction was performed to identify NDM-1, KPC, OXA-48, VIM and IMP genes. Demographic data and clinical characteristics were collected from the Hospital Information System. The prevalence of CRE in 2015 and 2016 was 0.3% (5/1590) and 1.2% (17/1402) respectively. 65% of the patients had underlying haematological disorders. Majority (81.8%) of the isolates were Klebsiella pneumoniae, followed by Serratia marcescens, Escherichia coli, and Citrobacter koseri. Klebsiella pneumoniae that co-produced NDM-1 and OXA48 genes were the most common encounter (41%), followed by OXA-48 (35%), NDM-1 (12%) and KPC (6%). All isolates were resistant to all generations of cephalosporin and carbapenem. The rate of resistance to tigecycline, polymyxin B and colistin were quite high; 46% (5 from 12 isolates), 17% (2/12) and 17% (3/17) respectively. The prevalence of CRE in this institution was relatively low. However, there is a high prevalence of OXA-48 and NDM co-producer amongst CRE isolates. Physicians should have high index of CRE suspicion in hematological patients. � 2018, Malaysian Society for Parasitology. All rights reserved.
dc.description.natureFinalen_US
dc.identifier.epage307
dc.identifier.issn1275720
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85052082417
dc.identifier.spage300
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85052082417&partnerID=40&md5=dc3e4cda5176b0d65f4fd2c11f8313cd
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9134
dc.identifier.volume35
dc.languageEnglish
dc.language.isoen_US
dc.publisherMalaysian Society for Parasitologyen_US
dc.relation.ispartofTropical Biomedicine
dc.sourceScopus
dc.titleCarbapenem-resistant enterobactericeae: Clinico-epidemiological perspective
dc.typeArticleen_US
dspace.entity.typePublication

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