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Production of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supports

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dc.Chemicals/CASbutyric acid, 107-92-6, 156-54-7, 461-55-2; drostanolone propionate, 521-12-0; triacylglycerol lipase, 9001-62-1
dc.citedby23
dc.contributor.affiliationsFaculty of Science and Technology
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Putra Malaysia (UPM)
dc.contributor.affiliationsUniversiti Teknologi MARA (UiTM)
dc.contributor.authorOthman S.S.en_US
dc.contributor.authorBasri M.en_US
dc.contributor.authorHussein M.Z.en_US
dc.contributor.authorAbdul Rahman M.B.en_US
dc.contributor.authorRahman R.N.Z.Abd.en_US
dc.contributor.authorSalleh A.B.en_US
dc.contributor.authorJasmani H.en_US
dc.date.accessioned2024-05-29T01:56:42Z
dc.date.available2024-05-29T01:56:42Z
dc.date.issued2008
dc.description.abstractOptically active (-)-menthyl butyrate was synthesized by enantioselective esterification of racemic (±)-menthol and butyric anhydride using lipase from Candida rugosa immobilized onto epoxy-activated supports of Eupergit C and Eupergit C 250 L through physical adsorption method. The effects of various temperature, storage condition, stability in organic solvent and lipase recyclability were investigated for their influence on the enzymatic enantioselective formation of (-)-menthyl butyrate. The immobilized lipases retained high catalytic activity of up to 31% yield and 100% enantiomeric excess of the desired product, and showed better stability compared to the native lipase. They also exhibited about 50% retained activity even after incubation at higher temperatures, storage at room temperature and after long incubation in hexane. Immobilized lipases also showed considerably efficient reusability.en_US
dc.description.natureFinalen_US
dc.identifier.CODENFOCHD
dc.identifier.doi10.1016/j.foodchem.2007.04.026
dc.identifier.epage443
dc.identifier.issn3088146
dc.identifier.issue2
dc.identifier.scopus2-s2.0-34548292441
dc.identifier.spage437
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34548292441&doi=10.1016%2fj.foodchem.2007.04.026&partnerID=40&md5=84cd147ff0dde7c53d9c4d4562460fbf
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9863
dc.identifier.volume106
dc.languageEnglish
dc.language.isoen_USen_US
dc.relation.ispartofFood Chemistry
dc.sourceScopus
dc.subjectEnantioselectivityen_US
dc.subjectEpoxideen_US
dc.subjectImmobilizationen_US
dc.subjectLipaseen_US
dc.subjectMenthyl butyrateen_US
dc.titleProduction of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supportsen_US
dc.title.alternativeFood Chem.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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