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The effect of gamma irradiation on the chemical structure and surface characteristics of dipalmitoylphosphatidylcholine (DPPC) [Kesan sinaran gama ke atas struktur kimia dan ciri permukaan dipalmitoilfosfatidilkolina (DPPC)]

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dc.citedby2
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorMohd H.M.K.en_US
dc.contributor.authorAhmad A.F.en_US
dc.contributor.authorMohamed F.en_US
dc.contributor.authorKamaruzaman N.S.en_US
dc.contributor.authorLing N.W.en_US
dc.contributor.authorJin P.R.en_US
dc.contributor.authorYasir M.S.en_US
dc.contributor.authorMohd Hafez Mohd Isaen_US
dc.contributor.authorRamli S.en_US
dc.contributor.authorRadiman S.en_US
dc.contributor.authorRahman I.A.en_US
dc.date.accessioned2024-05-29T02:03:24Z
dc.date.available2024-05-29T02:03:24Z
dc.date.issued2013
dc.descriptionMalaysian Journal of Analytical Sciences, Vol 17No 3(2013): 454 -460en_US
dc.description.abstractDipalmitoylphosphatidylcholine (DPPC) is one of the most abundant lipids in the human body and carries out important physiological functions such as liver protection and fighting infections. This study was conducted to investigate the effect of ionising radiation on the chemical structure and surface characteristic of DPPC. Synthetic DPPC was dissolved in chloroform (1mg/ml) and irradiated with Cobalt-60 (dose range of 50 - 200 Gy). The change in surface characteristics due to gamma irradiation was determined by means of monolayer compression isotherms using a Langmuir trough. From the change in the isotherm features, the threshold dose that affected the surface characteristics of the DPPC monolayer was determined to be 60 Gy. With increasing dose value, the plateau feature in the DPPC isotherm became shorter and was shifted to higher surface pressures. Analysis using High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) suggested that gamma irradiation of DPPC destroyed the chemical structure of DPPC and produced two main radiolytic products, namely lisophosphatidylcholine, LPC (~495.3142 g/mol) and phosphatidic acid, PA (~718.916 g/mol) with an average percentage of LPC and PA of 23% and 74%, respectively.en_US
dc.description.natureFinalen_US
dc.identifier.epage460
dc.identifier.issn13942506
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84888880799
dc.identifier.spage454
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84888880799&partnerID=40&md5=5cf6d87c70a0bd4ee5f1ba3dbc4beff8
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10256
dc.identifier.volume17
dc.languageEnglish; Malay
dc.language.isoen_USen_US
dc.relation.ispartofMalaysian Journal of Analytical Sciencesen_US
dc.sourceScopus
dc.subjectDipalmitoylphosphatidylcholine (DPPC)en_US
dc.subjectGamma radiationen_US
dc.subjectHigh Performance Liquid-Chromatography (HPLC)en_US
dc.subjectLangmuir monolayeren_US
dc.subjectMass-Spectrometer (MS)en_US
dc.titleThe effect of gamma irradiation on the chemical structure and surface characteristics of dipalmitoylphosphatidylcholine (DPPC) [Kesan sinaran gama ke atas struktur kimia dan ciri permukaan dipalmitoilfosfatidilkolina (DPPC)]en_US
dc.typeArticleen_US
dspace.entity.typePublication

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