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Distinct Microrna Expression Pattern in Breast Cancer Cells Following Anti-neoplastic Treatment: A Systematic Review and Functional Analysis of Microrna Target Genes

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dc.contributor.authorDerani Qatrun Nadaen_US
dc.contributor.authorMuhammad Lasim Masnizaen_US
dc.contributor.authorNatasya Abdullahen_US
dc.contributor.authorMuhamad Marlinien_US
dc.contributor.authorMarjanu Hikmah Eliasen_US
dc.contributor.authorSiva Gowri Pathmanathanen_US
dc.contributor.authorAbdul Rahman Hayatien_US
dc.contributor.authorFauzi Fadlul Azimen_US
dc.contributor.authorAdila Abdul Hamiden_US
dc.contributor.authorMohd Manzor Nur Farihaen_US
dc.date.accessioned2024-05-29T02:04:05Z
dc.date.available2024-05-29T02:04:05Z
dc.date.issued2022
dc.date.submitted2023-2-9
dc.descriptionVolume :44 No: 3 (page: 367 – 385)en_US
dc.description.abstractBreast cancer remains a significant cause of mortality in females worldwide, despite advances in technology and treatment. MicroRNA expression in breast cancer is studied both as potential biomarkers and for therapeutic purposes. Accumulated evidence revealed microRNA profile of various types of cancer cells following antineoplastic treatment. The progression of research in this area provides better understanding on the anti-cancer mechanism of various natural compounds and drugs specifically on the microRNA regulation. Hence, we aim to systematically review differentially expressed microRNA in MCF-7, a commonly studied breast cancer cell line, after treatment with anti-neoplastic agents. Relevant keywords were used to screen for research articles that reported on the differentially expressed microRNAs in experimental models of MCF-7 before and after anti-neoplastic treatment. Target genes of microRNAs were identified from MiRTarbase and further in silico functional analysis of the target genes were performed using DAVID bioinformatic resources. Two upregulated microRNAs (mir-200c and let-7d) and 3 downregulated microRNAs (mir-27a, mir-27b and mir-203) were identified by highest number of studies. Three microRNAs (let-7a, mir-23a and mir-7) showed inconsistent direction of expression. Genes functional analysis revealed the regulatory effect of microRNA on genes related to angiogenesis, hypoxia, P53, FoxO and PI3K-AKT signalling. Clusters of genes associated to the pathway of angiogenesis, cancers, cell proliferation and apoptosis were noted through protein-protein interaction analysis. MicroRNAs, especially the mir-200c, let-7d, mir-27a, mir-27b and mir-203 from this review could be further validated experimentally to serve as molecular target or biomarkers for anti-neoplastic therapyen_US
dc.identifier.citationD Qatrun Nada, Masniza, M. L., Abdullah, N., M Marlini, Elias, M. H., Pathmanathan, S. G., Hayati, A. R., F Fadlul Azim, Hamid, A. A., & Nur, M. (2022). Distinct microRNA expression pattern in breast cancer cells following anti-neoplastic treatment: A systematic review and functional analysis of microRNA target genes. PubMed, 44(3), 367–385.en_US
dc.identifier.epage385
dc.identifier.issn0126-8635
dc.identifier.issue3
dc.identifier.spage367
dc.identifier.urihttp://www.mjpath.org.my/2022/v44n3/breast-cancer.pdf
dc.identifier.urihttps://www.scopus.com/results/results.uri?sort=plf-f&src=s&st1=Distinct+Microrna+Expression+Pattern+In+Breast+Cancer+Cells+Following+Anti-neoplastic+Treatment%3A+A+Systematic+Review+And+Functional+Analysis+Of+Microrna+Target+Genes&sid=3c6fb43e6ebe881c30216628f03f72ed&sot=b&sdt=b&sl=180&s=TITLE-ABS-KEY%28Distinct+Microrna+Expression+Pattern+In+Breast+Cancer+Cells+Following+Anti-neoplastic+Treatment%3A+A+Systematic+Review+And+Functional+Analysis+Of+Microrna+Target+Genes%29&origin=searchbasic&editSaveSearch=&yearFrom=Before+1960&yearTo=Present&sessionSearchId=3c6fb43e6ebe881c30216628f03f72ed&limit=10
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10282
dc.identifier.volume44
dc.language.isoen_USen_US
dc.publisherCollege of Pathologists, Academy of Medicine Malaysiaen_US
dc.relation.ispartofMalaysian Journal Of Pathologyen_US
dc.subjectBreast cancer; MCF-7; miRNA; gene expression profiling; pathway anaysisen_US
dc.titleDistinct Microrna Expression Pattern in Breast Cancer Cells Following Anti-neoplastic Treatment: A Systematic Review and Functional Analysis of Microrna Target Genesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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