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DNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population

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dc.Chemicals/CASmalonaldehyde, 542-78-9; Malondialdehyde
dc.FundingDetailsUniversiti Kebangsaan Malaysia: DIP-2015-004 Ministry of Higher Education, Malaysia: LRGS/BU/2012/ UKM-UKM/K/04
dc.FundingDetailsThis study was supported by Ministry of Education, Malaysia under Long-term Research Grant Scheme [LRGS/BU/2012/ UKM-UKM/K/04] and Universiti Kebangsaan Malaysia (UKM) Research Grant DIP-2015-004.
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM) Medical Centre
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Teknologi MARA (UiTM)
dc.contributor.authorAbdul Sani N.F.en_US
dc.contributor.authorAhmad Damanhuri M.H.en_US
dc.contributor.authorAmir Hamzah A.I.Z.en_US
dc.contributor.authorAbu Bakar Z.H.en_US
dc.contributor.authorTan J.-K.en_US
dc.contributor.authorNor Aripin K.N.en_US
dc.contributor.authorMohd Rani M.D.en_US
dc.contributor.authorNoh N.A.en_US
dc.contributor.authorShamaan N.A.en_US
dc.contributor.authorRazali R.en_US
dc.contributor.authorMohd Yusof Y.A.en_US
dc.contributor.authorMazlan M.en_US
dc.contributor.authorMakpol S.en_US
dc.contributor.authorWan Ngah W.Z.en_US
dc.date.accessioned2024-05-28T08:25:46Z
dc.date.available2024-05-28T08:25:46Z
dc.date.issued2018
dc.description.abstractAgeing is associated with increased oxidative stress accompanied by cognitive decline. The aim of this study was to evaluate oxidative stress biomarkers and their possible relationship with cognitive performances during ageing among the Malay population. Approximately 160 healthy Malay adults aged between 28 and 79 years were recruited around Selangor and Klang Valley. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA), forward digit span (FDS), backward digit span (BDS), digit symbol, Rey Auditory Verbal Learning Test immediate recalled [RAVLT(I)] and delayed recalled [RAVLT(D)], and visual reproduction immediate recalled (VR-I) and delayed recalled (VR-II). DNA damage, plasma protein carbonyl and malondialdehyde (MDA) levels were also determined. Cognitive function test showed significant lower scores of MoCA, BDS, RAVLT(I), RAVLT(D), digit symbol, VR-I, and VR-II in the older age group (60 years old) compared with the 30-, 40-, and 50-year-old group. The extent of DNA damage was sequential with age: 60 > 50 > 40 > 30, whereas protein carbonyl was higher in 40-, 50-, and 60-year-old groups compared with the youngest group (30 years old). However, the MDA level was observed unchanged in all age groups. Approximately 21.88% of the participants had cognitive impairment. Multiple logistic regression analysis revealed that DNA damage and protein carbonyl levels are predictors for cognitive impairment in healthy Malays. In conclusion, cognitive decline occurred in healthy adult Malay population at an early age of 30 years old with corresponding higher DNA damage and protein oxidation. � 2018, � 2018 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.description.natureFinalen_US
dc.identifier.CODENFRARE
dc.identifier.doi10.1080/10715762.2018.1506877
dc.identifier.epage1009
dc.identifier.issn10715762
dc.identifier.issue9
dc.identifier.pmid30079776
dc.identifier.scopus2-s2.0-85053809363
dc.identifier.spage1000
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053809363&doi=10.1080%2f10715762.2018.1506877&partnerID=40&md5=0ba6a82ae3a7fd13960ab557fe09713d
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8678
dc.identifier.volume52
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofFree Radical Research
dc.sourceScopus
dc.subjectageingen_US
dc.subjectcognitive impairmenten_US
dc.subjectcross-sectional studyen_US
dc.subjectOxidative Stressen_US
dc.titleDNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian populationen_US
dc.title.alternativeFree Radic. Res.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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