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Cytotoxicity and Inhibition of Nitric Oxide in Lipopolysaccharide Induced Mammalian Cell Lines by Aqueous Extracts of Brown Seaweed

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dc.contributor.authorJaswir, Ien_US
dc.contributor.authorMonsur, HAen_US
dc.contributor.authorSimsek, Sen_US
dc.contributor.authorAmid, Aen_US
dc.contributor.authorAlam, Zen_US
dc.contributor.authorbin Salleh, MNen_US
dc.contributor.authorTawakalit, AHen_US
dc.contributor.authorOctavianti, Fen_US
dc.date.accessioned2024-05-29T03:25:01Z
dc.date.available2024-05-29T03:25:01Z
dc.date.issued2014
dc.description.abstractAqueous extracts obtained from five Malaysian brown seaweeds, Sargassum duplicatum, Sargassum binderi, Sargassum fulvellum, Padina australis, and Turbinaria turbinata, were investigated for their abilities to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-induced macrophage RAW 264.7 cell lines as well as to determine their chemical composition. The percentage yield of extracts varied among species, with P australis having the lowest yield and E turbinata having the highest yield. The chemical compositions of the extracts showed that the percentage of sulfate ions as well as uronic acid and total sugar content varied significantly. All extracts contained high fucose and inhibited NO secretion in a dose-dependent manner. Extracts of P australis and T turbinate dosed at 200 mu g/mL were able to inhibit NO secretion by > 75%. Furthermore, cytotoxicity assays revealed that some extracts were moderately toxic, while others were not. Based on these results, brown seaweed of Malaysian origin should be investigated for the production of additional anti-inflammatory compounds.en_US
dc.identifier.doi10.5650/jos.ess13185
dc.identifier.epage794
dc.identifier.issn1345-8957
dc.identifier.issue8
dc.identifier.scopusWOS:000339539900006
dc.identifier.spage787
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11839
dc.identifier.volume63
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherJapan Oil Chemists Socen_US
dc.relation.ispartofJournal Of Oleo Scienceen_US
dc.sourceWeb Of Science (ISI)
dc.subjectanti-inflammatoryen_US
dc.subjectmacro-algaeen_US
dc.subjectpolysaccharideen_US
dc.subjectfucoidanen_US
dc.subjectcytotoxicityen_US
dc.titleCytotoxicity and Inhibition of Nitric Oxide in Lipopolysaccharide Induced Mammalian Cell Lines by Aqueous Extracts of Brown Seaweeden_US
dc.typeArticleen_US
dspace.entity.typePublication

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