Publication:
In vitro and in vivo effects of Puntius javanicus cholinesterase by copper

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dc.citedby9
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Putra Malaysia (UPM)
dc.contributor.affiliationsUniversiti Malaysia Sabah (UMS)
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.authorSabullah M.K.en_US
dc.contributor.authorSulaiman M.R.en_US
dc.contributor.authorShukor M.Y.A.en_US
dc.contributor.authorShamaan N.A.en_US
dc.contributor.authorKhalid A.en_US
dc.contributor.authorAhmad S.A.en_US
dc.date.accessioned2024-05-28T08:29:33Z
dc.date.available2024-05-28T08:29:33Z
dc.date.issued2015
dc.description.abstractThe aim of this study is to determine the inhibitory effect of copper towards butyrylcholinesterase (BChE) activity. Using the Lineweaver-Burk plot, Puntius javanicus BChE activity was found to be noncompetitively inhibited by copper. The maximal velocities of untreated (control) BChE, 0.5 and 10 mg/L copper-treated BChE are 53.70, 31.81 and 14.30 Umg-1, respectively, while the biomolecular constant (Km) values of both tests shows no significant difference (p>0.05). The in vitro IC50 of copper ion to the BChE was found to be 0.0948 (0.0658 to 0.1691) mg/L. In vivo tests showed that in the presence of 0.1 mg/L copper, the BChE activity was slightly higher compared to the untreated control. Copper sulfate at 0.3 mg/L concentration showed no significant inhibition compared to control. However, the activity decreased with increasing copper concentrations of 0.5, 1.0 and 5.0 mg/L, with the remaining activity at 87.60, 84.60 and 73.00 %, respectively. This study suggests that BChE isolated from P. javanicus liver tissue is a potentially new source of biomarker for copper contamination. � by PSP.en_US
dc.description.natureFinalen_US
dc.identifier.CODENFENBE
dc.identifier.epage4621
dc.identifier.issn10184619
dc.identifier.issue12B
dc.identifier.scopus2-s2.0-84958163599
dc.identifier.spage4615
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84958163599&partnerID=40&md5=86857a4c5c5cf5e37dfe3d87e898ca54
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8909
dc.identifier.volume24
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherParlar Scientific Publicationsen_US
dc.relation.ispartofFresenius Environmental Bulletin
dc.sourceScopus
dc.subjectButyrylcholinesterase (BChE)en_US
dc.subjectCopperen_US
dc.subjectP. javanicusen_US
dc.titleIn vitro and in vivo effects of Puntius javanicus cholinesterase by copperen_US
dc.title.alternativeFresenius Environ. Bull.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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