Publication:
Effect Of Kenaf Seed Oil From Different Ways Of Extraction Towards Ovarian Cancer Cells

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dc.contributor.authorSiti Aisyah Abd Ghafaren_US
dc.contributor.authorLatifah Saiful Yazanen_US
dc.contributor.authorJhi Biau Fooen_US
dc.contributor.authorKim Wei Chanen_US
dc.contributor.authorParidah Md Tahiren_US
dc.contributor.authorMaznah Ismailen_US
dc.date.accessioned2024-05-27T14:43:37Z
dc.date.available2024-05-27T14:43:37Z
dc.date.issued2011
dc.date.submitted--
dc.descriptionFood and Bioproducts Processing Volume 89, Issue 4, October 2011, Pages 328-332en_US
dc.description.abstractKenaf (Hibiscus cannabinus) from the family of Malvaceae is a valuable fibre plant native to India and Africa. Kenafis composed of various active components including tannins, saponins, polyphenolics, alkaloids, essential oils andsteroids. It has been used to treat bruises, bilious conditions, fever and puerperium. Nevertheless, the anti-cancer properties of kenaf seed oil have not yet been investigated. In this study, kenaf seed oils obtained by Sonication,Soxhlet and supercritical carbon dioxide fluid extraction (SFE) with 9 different combinations of pressure (bars) and temperature (◦C) (200/40, 200/60, 200/80, 400/40, 400/60, 400/80, 600/40, 600/60 and 600/80) were investigated for the cytotoxicities. All the oils were cytotoxic towards ovarian cancer (CaOV3) and colon cancer (HT29) cell lines in a dose dependent manner as detected by using the MTT assay and trypan blue dye exclusion method. Oil from Sonication was the most cytotoxic towards CaOV3 cell line. Treated cells exhibited characteristics of apoptosis such as chromatin condensation and nuclear fragmentation. In conclusion, kenaf seed oils from the three extractions were cytotoxic towards CaOV3 cell line in a dose-dependent manner possibly via the induction of apoptosis. In considering the safety of the product, SFE technology is a better alternative extraction method that is suitable in kenaf seed oil extractionen_US
dc.identifier.doihttps://doi.org/10.1016/j.fbp.2010.10.007
dc.identifier.epage332
dc.identifier.issn0960-3085
dc.identifier.spage328
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0960308510001112
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/3679
dc.identifier.volume89
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofFood and Bioproducts Processingen_US
dc.subjectSupercritical carbon dioxide fluid extraction;en_US
dc.subjectKenaf (H. cannabinus) seed oil;en_US
dc.subjectCytotoxicity;en_US
dc.subjectApoptosisen_US
dc.titleEffect Of Kenaf Seed Oil From Different Ways Of Extraction Towards Ovarian Cancer Cellsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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