Publication:
Hemoglobinopathies and thalassemia screening among Senoi Orang Asli in Peninsular Malaysia

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dc.Conferencecode116782
dc.Conferencedate15 April 2015 through 16 April 2015
dc.Conferencename2015 Postgraduate Colloquium of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology, UKM FST 2015
dc.citedby1
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM) Medical Centre
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorRong D.K.X.en_US
dc.contributor.authorIsmail E.en_US
dc.contributor.authorSabudin R.Z.A.R.en_US
dc.contributor.authorHussin N.H.en_US
dc.contributor.authorOthman A.en_US
dc.date.accessioned2024-05-28T08:25:18Z
dc.date.available2024-05-28T08:25:18Z
dc.date.issued2015
dc.description.abstractOrang Asli are the minority indigenous people in Peninsular Malaysia and can be divided into 3 main groups (Negrito, Senoi and Proto Malay) with different six sub-ethnics under each group. Within the Senoi group, the six sub-ethnics are sub-ethnic Mah Meri, Semoq Beri, Che Wong, Jah Hut, Semai and Temiar. This study was aimed to investigate the current prevalence of ?- and ?-thalassemia and hemoglobinopathies and their mutation types among all six sub-ethnics of Senoi Orang Asli. Blood samples from 685 Senoi participants were collected and sent immediately for routine full blood count analysis and hemoglobin sub-typing. Of 378 subjects screened, 7 subjects were found to be Hemoglobin E (HbE) beta thalassemia carriers, 13 beta thalassaemic, 35 Hemoglobin Constant Spring (HbCS) carriers, 6 compound HbE and HbCS carriers, 32 with HbE disease and 163 HbE heterozygote carriers. The findings of high HbE among Temiars and Jah Huts and high HbCS exclusively in Jah Huts in this study suggest distinct differences across sub-ethnics under Senoi group. Understanding of prevalence and wide spectrum of thalassemia and hemoglobinopathies among Senoi and Orang Asli is essential for national thalassaemia awareness and prevention program, especially in Orang Asli communities. � 2015 AIP Publishing LLC.
dc.description.natureFinalen_US
dc.editorNadzir M.S.M.Samsudin H.B.Hanafiah M.M.Ahmad A.Hassan N.I.Hazmi I.R.Agustar H.K.Ibarahim Z.Ibrahim N.B.Abu Bakar S.Noorani M.S.M.Karim N.H.A.Zubairi S.I.Ibrahim N.en_US
dc.identifier.ArtNo30033
dc.identifier.doi10.1063/1.4931254
dc.identifier.isbn9780740000000
dc.identifier.issn0094243X
dc.identifier.scopus2-s2.0-84958787200
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84958787200&doi=10.1063%2f1.4931254&partnerID=40&md5=257ae4425f55fb38a7f685444d5c3374
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8632
dc.identifier.volume1678
dc.languageEnglish
dc.language.isoen_US
dc.publisherAmerican Institute of Physics Inc.en_US
dc.relation.ispartofAIP Conference Proceedings
dc.sourceScopus
dc.titleHemoglobinopathies and thalassemia screening among Senoi Orang Asli in Peninsular Malaysia
dc.typeConference Paperen_US
dspace.entity.typePublication

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