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Incorporation of silver nanoparticles (AgNPs) with endophytes cell-free secondary metabolites enhances antimicrobial activity

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dc.FundingDetailsUniversiti Kebangsaan Malaysia,�UKM: DLP-2-14-021
dc.FundingDetailsWe would like to thank Universiti Kebangsaan Malaysia for providing funding for this project DLP-2-14-021.
dc.contributor.affiliationsFaculty of Dentistry
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorAhmad Syairazie Ibrahim Fikrien_US
dc.contributor.authorIrman Abdul Rahmanen_US
dc.contributor.authorAinon Hamzahen_US
dc.contributor.authorSiti Noor Adnalizawati Adnanen_US
dc.contributor.authorNorefrina Shafinaz Md Noren_US
dc.date.accessioned2024-05-28T08:42:47Z
dc.date.available2024-05-28T08:42:47Z
dc.date.issued2018
dc.date.submitted--
dc.description.abstractIn our previous study, we isolated eight bacterial endophytes with positive antimicrobial activity out of 82 isolates from five different places in Pulau Langkawi. The antimicrobial activity of the endophytes secondary metabolite although moderate, was further explored for the prospect to be enhanced by incorporating to silver nitrates. Only two isolates were able to synthesise silver nanoparticles namely Bacillus subtilis (B7b) and Pseudomonas resinovorans (B2c) within 72 hours of incubation at room temperature via extracellular method. Antimicrobial assay against Staphylococcus aureus, methicilin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermis, Escherichia coli and Pseudomonas aeruginosa was performed. Synthesised silver nanoparticles (AgNPs) showed excellent inhibitory effect against both Gram positive and Gram negative bacteria but secondary metabolites without AgNPs showed positive activity only against Gram positive bacteria. The results suggested that incorporation of AgNPs was able to enhance antimicrobial activity of secondary metabolites of B7b and B2c against test bacteria. � 2019, Malaysian Society of Applied Biology. All rights reserved.en_US
dc.description.natureFinal
dc.identifier.citationIBRAHIM FIKRI, . A. S. ., RAHMAN, I. A. ., HAMZAH, A. ., ADNAN, S. N. A., & MD NOR, N. S. . (2018). INCORPORATION OF SILVER NANOPARTICLES (AgNPs) WITH ENDOPHYTES CELL-FREE SECONDARY METABOLITES ENHANCES ANTIMICROBIAL ACTIVITY. Malaysian Applied Biology, 47(5), 283–288. Retrieved from https://jms.mabjournal.com/index.php/mab/article/view/2126en_US
dc.identifier.epage288
dc.identifier.issn1268643
dc.identifier.issue5
dc.identifier.other1975-11
dc.identifier.scopus2-s2.0-85059328250
dc.identifier.spage283
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059328250&partnerID=40&md5=d9ebf6bb383df982dab5d6198baaca14
dc.identifier.urihttps://jms.mabjournal.com/index.php/mab/article/view/2126
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9331
dc.identifier.volume47
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherMalaysian Society of Applied Biologyen_US
dc.relation.ispartofMalaysian Applied Biologyen_US
dc.sourceScopus
dc.subjectAntibacterialen_US
dc.subjectBiosynthesisen_US
dc.subjectMultidrug-resistant bacteria (MDR)en_US
dc.subjectSilver nanoparticles (AgNPs)en_US
dc.titleIncorporation of silver nanoparticles (AgNPs) with endophytes cell-free secondary metabolites enhances antimicrobial activityen_US
dc.typeArticleen_US
dspace.entity.typePublication

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