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Synthesis, characterization and anticancer activity of mono- and dinuclear Ni(II) and Co(II) complexes of a Schiff base derived from o-vanillin

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dc.contributor.authorBahron, Hen_US
dc.contributor.authorKhaidir, SSen_US
dc.contributor.authorTajuddin, AMen_US
dc.contributor.authorRamasamy, Ken_US
dc.contributor.authorYamin, BMen_US
dc.date.accessioned2024-05-29T02:51:16Z
dc.date.available2024-05-29T02:51:16Z
dc.date.issued2019
dc.descriptionPolyhedron Volume 161, 15 March 2019, Pages 84-92en_US
dc.description.abstractA Schiff base ligand, 6,6'-dimethoxy-2,2'-[o-phenylenebis(nitrilomethylidyne)]diphenolato (LA), and its mononuclear and dinuclear Ni(II) and Co(II) complexes were synthesized. Structural elucidation was carried out via elemental analysis, molar conductivity, IR, NMR, UV-Vis spectroscopy, TGA and magnetic susceptibility. Single crystal X-ray diffraction of the Ni(LA) complex revealed a square planar geometry of the Ni(II) centre, with the ligand acting as a tetradentate ONNO chelate. Upon coordination to the metal centers, the nu(C=N) and nu(C-O) peaks shifted to lower frequencies, with appearance of new peaks assignable to nu(M-N) and nu(M-O) in the ranges 535-560 and 421-460 cm(-1), respectively. Ni(LA) and Ni-2(LA) complexes are diamagnetic, whereas the Co(LA) and Co-2(LA) complexes are paramagnetic with 3 unpaired electrons each. All the complexes displayed low molar conductivities in acetonitrile indicating non-electrolytic behavior. Anticancer screening against human colorectal cancer HCT116 cell lines revealed that both dinuclear complexes were more active than their mononuclear counterparts. Ni-2(LA) showed the highest potency with an IC50 value of 0.81 mu M. (C) 2019 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.poly.2018.12.055
dc.identifier.epage92
dc.identifier.issn0277-5387
dc.identifier.scopusWOS:000460495900009
dc.identifier.spage84
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060229906&doi=10.1016%2fj.poly.2018.12.055&partnerID=40&md5=f934a8202617f7f192acf1406ab36817
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11175
dc.identifier.volume161
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPolyhedronen_US
dc.sourceWeb Of Science (ISI)
dc.subjectMononuclearen_US
dc.subjectDinuclearen_US
dc.subjectComplexesen_US
dc.subjectSchiff baseen_US
dc.subjectAnticanceren_US
dc.titleSynthesis, characterization and anticancer activity of mono- and dinuclear Ni(II) and Co(II) complexes of a Schiff base derived from o-vanillinen_US
dc.typeArticleen_US
dspace.entity.typePublication

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