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Unravelling the Role Of Has2, Grem1, and Ptgs2 Gene Expression in Cumulus Cells: Implications for Human Oocyte Development Competency - A Systematic Review and Integrated Bioinformatic Analysis

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dc.contributor.authorAhmad Mohd Faizal
dc.contributor.authorMarjanu Hikmah Elias
dc.contributor.authorNorazilah Mat Jin
dc.contributor.authorMuhammad Azrai Abu
dc.contributor.authorSaiful Effendi Syafruddin
dc.contributor.authorAni Amelia Zainuddin
dc.contributor.authorNao Suzuki
dc.contributor.authorAbdul Kadir Abdul Karim
dc.date.accessioned2024-07-13T15:16:00Z
dc.date.available2024-07-13T15:16:00Z
dc.date.issued2024
dc.date.submitted2024-6-26
dc.descriptionFrontiers in Endocrinology Volume 15
dc.description.abstractThe leading indicator for successful outcomes in in-vitro fertilization (IVF) is the quality of gametes in oocytes and sperm. Thus, advanced research aims to highlight the parameter in assessing these qualities – DNA fragmentation in sperm and oocyte development capacity (ODC) via evaluation of microenvironments involving its maturation process. Regarding oocytes, most evidence reveals the role of cumulus cells as non-invasive methods in assessing their development competency, mainly via gene expression evaluation. Our review aims to consolidate the evidence of GDF-9 derivatives, the HAS2, GREM1, and PTGS2 gene expression in cumulus cells used as ODC markers in relevant publications and tailored to current IVF outcomes. In addition to that, we also added the bioinformatic analysis in our review to strengthen the evidence aiming for a better understanding of the pathways and cluster of the genes of interest - HAS2, GREM1, and PTGS2 in cumulus cell level. Otherwise, the current non-invasive method can be used in exploring various causes of infertility that may affect these gene expressions at the cumulus cell level. Nevertheless, this method can also be used in assessing the ODC in various cohorts of women or as an improvement of markers following targeted tools or procedures by evaluating the advancement of these gene expressions following the targeted intervention.
dc.identifier.citationAhmad Mohd Faizal, Marjanu Hikmah Elias, Norazilah Mat Jin, Muhammad Azrai Abu, Saiful Effendi Syafruddin, Ani Amelia Zainuddin, Suzuki, N., & Abdul Kadir Abdul Karim. (2024). Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis. Frontiers in Endocrinology, 15. https://doi.org/10.3389/fendo.2024.1274376
dc.identifier.doi10.3389/fendo.2024.1274376
dc.identifier.epage12
dc.identifier.issn1664-2392
dc.identifier.issue1274376
dc.identifier.spage1
dc.identifier.urihttps://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1274376/full
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/20713
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85188238037&origin=resultslist&sort=plf-f&src=s&sid=d15cfab9d418fdabb4572806347dc343&sot=b&sdt=b&s=TITLE-ABS-KEY%28Unravelling+the+role+of+HAS2%2C+GREM1%2C%29&sl=95&sessionSearchId=d15cfab9d418fdabb4572806347dc343&relpos=0
dc.identifier.volume15
dc.language.isoen_US
dc.publisherFrontiers
dc.relation.ispartofFrontiers in Endocrinology
dc.relation.issn1664-2392
dc.relation.journalFrontiers in Endocrinology
dc.subjectcumulus cells
dc.subjectgene expression
dc.subjectgrem1
dc.subjectHAS2
dc.subjectoocytes development competency
dc.subjectPTGS2
dc.titleUnravelling the Role Of Has2, Grem1, and Ptgs2 Gene Expression in Cumulus Cells: Implications for Human Oocyte Development Competency - A Systematic Review and Integrated Bioinformatic Analysis
dc.typetext::journal::journal article
dspace.entity.typePublication
oaire.citation.volume15
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
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oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#

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