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Chikungunya confused with dengue in Malaysia: Clinical, serological and molecular perspective

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dc.Chemicals/CASimmunoglobulin M, 9007-85-6
dc.ManufacturersCorbett Research, Australia
dc.TradenamesOnsite; Rotor Gene 3000, Corbett Research, Australia
dc.citedby5
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorAli U.en_US
dc.contributor.authorIsahak I.en_US
dc.contributor.authorRahman M.M.en_US
dc.date.accessioned2024-05-29T01:54:59Z
dc.date.available2024-05-29T01:54:59Z
dc.date.issued2011
dc.description.abstractThis study was to observe clinical, serolgical and molecular diagnosis of chikungunya viral fever patients and its comparison with dengue viral fever. For that 49 serologically negative dengue patients but clinically dengue like symptomms were included. Clinical investigation was carried out recording different profiles of hospitalized patients. Serology was performed using the Onsite® Chikungunya IgM Combo rapid test and molecular test RT-PCR was performed to detect the virus in the patients sera. It was observed that out of them 19 (38.7 %) were serologically confirmed chikungunya infection. Interestingly molecular detection of the patients sera did not show the presence chikungunya virus but detected dengue virus from 9 patients's sera. Classical clinical features of chikungunya virus infected patients were recorded to differentiate chikungunya from dengue, which were fever, arthralgia, myalgia and rash. Detection of chikungunya IgM in these cohort means that this virus is circulating throughout the year although not as many as dengue. Laboratory confirmation is important to differentiate chikungunya fever from dengue fever. This study adds some information in local data and hopefully can help the clinicians to clinically and laboratory diagnosis and management of chikungunya infection in outbreak and non-outbreak setting. Serology was proven to be useful in confirming chikungunya infection.en_US
dc.description.natureFinalen_US
dc.identifier.issn19378289
dc.identifier.issue2
dc.identifier.scopus2-s2.0-79957566842
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79957566842&partnerID=40&md5=2d14a5a00ac0902f591df6807f8dd009
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9602
dc.identifier.volume9
dc.languageEnglish
dc.language.isoen_USen_US
dc.relation.ispartofInternet Journal of Microbiology
dc.sourceScopus
dc.subjectArthalgiaen_US
dc.subjectChikungunya virusen_US
dc.subjectDengue virusen_US
dc.subjectMolecularen_US
dc.subjectMyalgiaen_US
dc.subjectSerologyen_US
dc.titleChikungunya confused with dengue in Malaysia: Clinical, serological and molecular perspectiveen_US
dc.title.alternativeInternet J. Microbiol.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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