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Antioxidant, anticancer and antimicrobial activities of methanolic extracts from enicosanthellum pulchrum (King) heusden

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dc.contributor.authorNoraziah Nordinen_US
dc.contributor.authorSyam Mohanen_US
dc.contributor.authorNajihah Mohd. Hashimen_US
dc.date.accessioned2024-05-28T04:28:57Z
dc.date.available2024-05-28T04:28:57Z
dc.date.issued2014
dc.description.abstractBiological activities of crude methanolic extracts from leaves, barks, twigs and roots ofEnicosanthellum pulchrum were investigated in four bioassays. The antioxidant, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) scavenging assay showed that bark and twig extracts showed high inhibitory activity with 60 and 56% inhibition at 1 mglmL and IC50values of 0.43 t 0.04 and 0.64 t 0.05 mglmL, respectively. The bark and root extracts showed greater reducing power (FRAP) than several standard drugs used in the bioassay. Methanolic extracts of leaves, twigs and roots displayed strong cytotoxicity to breast cancer cell line (MCF-7), myelomonocytic leukaemia cell line (WEHI-3) and ovarian cancer cell line (CAOV-3); the IC50 of the leaf extract were 7.8 t 0.85 pg/mL (MCF-7) and 9.0 t 0.13 pgImL (WEHI-3), while those for the twig and root extracts were 13.9 t 0.35 and 7.3 t 0.98 pg/mL (CAOV-3), respectively. In the antimicrobial assays, the extracts were tested against ten bacterial strains and two fimgal strains. Bark and twig extracts displayed high inhibitory activity to Bacillus subtilis with 13.3 t 0.57 and 12.0 t 0.01 mm inhibition, respectively. In addition, the twig extract displayed better minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) compared with the bark extract (MIC 0.5 and 1.0 mg/mL, MBC 1.0 and 2.0 mg/mL, respectively). For antifitngal activity, all extracts showed inhibition on Candida albicans but not on Aspergillus niger. The obtained results suggested that this plant may possibly contain bioactive compounds in the active extracts.en_US
dc.identifier.citationNoraziah Nordin, and Syam Mohan, and Najihah Mohd. Hashim, and Asdren Zajm, and Noor Shafifiyaz Mohd. Yazid, and Mashitoh Abdul Rahman, and Fatima Abdelmutaal Ahmed Omer, and Hanita Omar, and Fatimah A'fifah Alias, and Hapipah Mohd. Ali, (2014) Antioxidant, anticancer and antimicrobial activities of methanolic extracts from enicosanthellum pulchrum (King) heusden. Sains Malaysiana, 43 (10). pp. 1515-1521. ISSN 0126-6039en_US
dc.identifier.epage0
dc.identifier.issn0-0
dc.identifier.issue10
dc.identifier.other2169-10
dc.identifier.spage1515–1521
dc.identifier.urihttp://www.ukm.my/jsm/english_journals/vol43num10_2014/vol43num10_2014p1515-1521.html
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/5730
dc.identifier.volume43
dc.language.isoenen_US
dc.publisherUniversiti Kebangsaan Malaysiaen_US
dc.relation.ispartofSains Malaysianaen_US
dc.subjectAnticancer, antimicrobial, antioxidant, Enicosanthellum pulchrum, methanolic extractsen_US
dc.titleAntioxidant, anticancer and antimicrobial activities of methanolic extracts from enicosanthellum pulchrum (King) heusdenen_US
dc.typeArticleen_US
dspace.entity.typePublication

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