Publication:
Influence of alloying elements on cellular response and in-vitro corrosion behavior of titanium-molybdenum-chromium alloys for implant materials

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dc.contributor.affiliationsFaculty of Dentistry
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.affiliationsUniversity of Sharjah
dc.contributor.authorNor Haliza Mat Baharinen_US
dc.contributor.authorMasfueh Razalien_US
dc.contributor.authorShahida Mohd-Saiden_US
dc.contributor.authorJunaidi Syarifen_US
dc.contributor.authorAndanastuti Muchtaren_US
dc.date.accessioned2024-05-29T02:50:07Z
dc.date.available2024-05-29T02:50:07Z
dc.date.issued2020
dc.descriptionJournal of Prosthodontic Research Volume 64, Issue 4, October 2020, Pages 490-497en_US
dc.description.abstractPurpose: Not all elements with beta-stabilizing properties in titanium alloys are suitable for biomaterial applications, because corrosion and wear processes release the alloying elements to the surrounding tissue. Chromium and molybdenum were selected as the alloying element in this work as to find balance between the strength and modulus of elasticity of beta-titanium alloys. This study aimed to investigate the effect of Titanium-10Molybdenum-10Chromium (Ti-10Mo-10Cr), Titanium-10Chromium (Ti-10Cr) and Titanium-10Molybdenum (Ti-10Mo) on the elemental leachability in tissue culture environment and their effect on the viability of human gingival fibroblasts (HGFs). Methods: Each alloy was immersed in growth medium for 0-21 days, and the elution was analyzed to detect the released metals. The elution was further used as the treatment medium and exposed to seeded HGFs overnight. The HGFs were also cultured directly to the titanium alloy for 1, 3 and 7 days. Cell viability was then determined. Results: Six metal elements were detected in the immersion of titanium alloys. Among these elements, molybdenum released from Ti-10Mo-10Cr had the highest concentration throughout the immersion period. Significant difference in the viability of fibroblast cells treated with growth medium containing metals and with direct exposure technique was not observed. The duration of immersion did not significantly affect cell viability. Nevertheless, cell viability was significantly affected after 1 and 7 days of exposure, when the cells were grown directly onto the alloy surfaces. Conclusions: Within the limitation of this study, the newly developed beta-titanium alloys are non-cytotoxic to human gingival fibroblasts. (C) 2020 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doihttps://doi.org/10.1016/j.jpor.2020.01.004
dc.identifier.epage497
dc.identifier.issn1883-1958
dc.identifier.issue4
dc.identifier.scopusWOS:000548101400021
dc.identifier.scopus2-s2.0-85079391943
dc.identifier.spage490
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85079391943&doi=10.1016%2fj.jpor.2020.01.004&partnerID=40&md5=630cebbb9b054cca1ac5396e7b56f861
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S1883195819302555?via%3Dihub
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10998
dc.identifier.volume64
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofJournal Of Prosthodontic Researchen_US
dc.sourceScopus
dc.subjectCytotoxicityen_US
dc.subjectbeta-titanium alloysen_US
dc.subjectTitanium alloysen_US
dc.subjectLeachable elementsen_US
dc.subjectTitanium-chromium alloysen_US
dc.subjectβ-titanium alloysen_US
dc.titleInfluence of alloying elements on cellular response and in-vitro corrosion behavior of titanium-molybdenum-chromium alloys for implant materialsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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