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Fatal Delayed Haemolytic Transfusion Reaction and Hyperhaemolysis Syndrome in a Pregnant Woman with Sickle Cell Anaemia

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dc.contributor.authorProf. Madya Dr. Asral Wirda Binti Ahmad Asnawien_US
dc.contributor.authorSathar, Jen_US
dc.contributor.authorMohamed, Ren_US
dc.contributor.authorDeraman, Ren_US
dc.contributor.authorKumaran, Sen_US
dc.contributor.authorAbd Hamid, SSen_US
dc.contributor.authorZakaria, MZen_US
dc.date.accessioned2024-05-29T02:50:58Z
dc.date.available2024-05-29T02:50:58Z
dc.date.issued2016
dc.description.abstractClinical manifestations of sickle cell disease (SCD) arise from the tendency of the sickle haemoglobin to polymerize and deform red blood cells into the characteristic sickle shape. Sickle cell crisis is a devastating complication that may occur in patients with SCD. If not managed properly permanent organ damage and even death may be the final outcome. A case of a 32-year-old Nigerian lady, Gravida 1 Para 0 in her first trimester, with SCD who developed signs and symptoms of delayed haemolytic transfusion reaction after receiving packed red cell transfusion is demonstrated. Multiple red cell alloantibodies were detected in the patient's plasma; anti-Fy a, anti-Jk b and anti-E. The patient miscarriaged and succumbed to complications of hyperhaemolysis with delayed haemolytic transfusion reaction, acute chest syndrome and renal failure. There is an urgent need for mandatory red cell antibody screen and identification especially in high-risk cases. Prevention of alloimmunization by supplying phenotype-specific red cells is also required.
dc.identifier.citationAsnawi, Asral & Sathar, Jameela & Mohamed, Rashidah & Deraman, Rohayu & Kumaran, Sri & Hamid, Shahada & Zakaria, Muhd. (2015). Fatal Delayed Haemolytic Transfusion Reaction and Hyperhaemolysis Syndrome in a Pregnant Woman with Sickle Cell Anaemia. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion. 32. 10.1007/s12288-014-0495-9.en_US
dc.identifier.doi10.1007/s12288-014-0495-9
dc.identifier.epageS253
dc.identifier.isbn0974-0449
dc.identifier.issn0971-4502
dc.identifier.scopusWOS:000378993400065
dc.identifier.spageS251
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11136
dc.identifier.volume32
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Hematology And Blood Transfusion
dc.sourceWeb Of Science (ISI)
dc.subjectSickle cell disease; Sickling; Hyperhaemolysis; Delayed haemolysis; Transfusion reactionen_US
dc.titleFatal Delayed Haemolytic Transfusion Reaction and Hyperhaemolysis Syndrome in a Pregnant Woman with Sickle Cell Anaemiaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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