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Optimization and formulation of fucoxanthin-loaded microsphere (F-LM) using response surface methodology (RSM) and analysis of its fucoxanthin release profile

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dc.Chemicals/CASfucoxanthin, 3351-86-8; xanthophyll, 127-40-2, 52842-48-5; Antineoplastic Agents; fucoxanthin; Xanthophylls
dc.FundingDetailsInternational Islamic University Malaysia International Islamic University Malaysia Universiti Sains Islam Malaysia International Islamic University Malaysia Ministry of Higher Education, Malaysia: MOHE 18-002-0002
dc.FundingDetailsInternational Institute for Halal Research and Training (INHART), International Islamic University Malaysia, Jalan Gombak, Kuala Lumpur 53100, Malaysia; dokterwidya@gmail.com (W.L.); science.abu@gmail.com (B.B.H.A.) Bioprocess and Molecular Engineering Research Unit (BPMERU), International Islamic University Malaysia (IIUM) Gombak, Kuala Lumpur 53100, Malaysia; ir98@hotmail.com Department of Pharmaceutical Technology, Universitas Ahmad Dahlan, Yogyakarta 55164, Indonesia Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia Kuantan, Kuantan 25200, Malaysia; mtaher@iium.edu.my (M.T.); farahidah@iium.edu.my (F.M.) Department of Orthodontics, Faculty of Dentistry, Universiti Sains Islam Malaysia, Tower B, Persiaran MPAJ, Jalan Pandan Utama, Kuala Lumpur 55100, Malaysia; yanti75@yahoo.com Ministry of Research, Technology and Higher Education of Indonesia, Senayan, Jakarta Pusat 10340, Indonesia; ghufronmukti@yahoo.com Chairman, Indonesia Halal Lifestyle Foundation, Jakarta 10230, Indonesia; bob.naedi@gmail.com Correspondence: irwandi@iium.edu.my; Tel.: +603-619-66-498
dc.FundingDetailsFunding: This research was funded by the Ministry of Higher Education Malaysia, KIHIM Research Grant MOHE 18-002-0002.
dc.contributor.affiliationsFaculty of Dentistry
dc.contributor.affiliationsInternational Islamic University Malaysia (IIUM)
dc.contributor.affiliationsUniversitas Ahmad Dahlan
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsMinistry of Research
dc.contributor.affiliationsHalal Lifestyle Foundation
dc.contributor.authorJaswir I.en_US
dc.contributor.authorNoviendri D.en_US
dc.contributor.authorTaher M.en_US
dc.contributor.authorMohamed F.en_US
dc.contributor.authorOctavianti F.en_US
dc.contributor.authorLestari W.en_US
dc.contributor.authorMukti A.G.en_US
dc.contributor.authorNirwandar S.en_US
dc.contributor.authorHamad Almansori B.B.en_US
dc.date.accessioned2024-05-28T08:25:18Z
dc.date.available2024-05-28T08:25:18Z
dc.date.issued2019
dc.descriptionJournals Molecules Volume 24 Issue 5en_US
dc.description.abstractFucoxanthin has interesting anticancer activity, but is insoluble in water, hindering its use as a drug. Microencapsulation is used as a technique for improving drug delivery. This study aimed to formulate fucoxanthin-loaded microspheres (F-LM) for anticancer treatment of H1299 cancer cell lines and optimize particle size (PS) and encapsulation efficiency (EE). Using response surface methodology (RSM), a face centered central composite design (FCCCD) was designed with three factors: Polyvinylalcohol (PVA), poly(D,L-lactic-co-glycolic acid) (PLGA), and fucoxanthin concentration. F-LM was produced using a modified double-emulsion solvent evaporation method. The F-LM were characterized for release profile, release kinetics, and degradation pattern. Optimal F-LM PS and EE of 9.18 um and 33.09%, respectively, with good surface morphology, were achieved from a 0.5% (w/v) PVA, 6.0% (w/v) PLGA, 200 ug/mL fucoxanthin formulation at a homogenization speed of 20,500 rpm. PVA concentration was the most significant factor (p < 0.05) affecting PS. Meanwhile, EE was significantly affected by interaction between the three factors: PVA, PLGA, and fucoxanthin. In vitro release curve showed fucoxanthin had a high burst release (38.3%) at the first hour, followed by a sustained release stage reaching (79.1%) within 2 months. Release kinetics followed a diffusion pattern predominantly controlled by the Higuchi model. Biodegradability studies based on surface morphology changes on the surface of the F-LM, show that morphology changed within the first hour, and F-LM completely degraded within 2 months. RSM under FCCCD design improved the difference between the lowest and highest responses, with good correlation between observed and predicted values for PS and EE of F-LM.en_US
dc.description.natureFinalen_US
dc.identifier.ArtNo947
dc.identifier.CODENMOLEF
dc.identifier.doi10.3390/molecules24050947
dc.identifier.isiWOS:000462662900123
dc.identifier.issn14203049
dc.identifier.issue5
dc.identifier.pmid30866561
dc.identifier.scopus2-s2.0-85062858873
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85062858873&doi=10.3390%2fmolecules24050947&partnerID=40&md5=a3d40adf1ae2e3584f7585c9ac124f05
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8633
dc.identifier.volume24
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofJournals Moleculesen_US
dc.sourceScopus
dc.subjectFucoxanthinen_US
dc.subjectMicroencapsulationen_US
dc.subjectMicrosphereen_US
dc.subjectRelease profileen_US
dc.subjectResponse surface methodologyen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectMicrospheresen_US
dc.titleOptimization and formulation of fucoxanthin-loaded microsphere (F-LM) using response surface methodology (RSM) and analysis of its fucoxanthin release profileen_US
dc.typeArticleen_US
dspace.entity.typePublication

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