Publication: Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates
| cris.lastimport.scopus | 2024-12-07T10:33:25Z | |
| cris.lastimport.wos | 2024-12-06T17:29:03Z | |
| dc.contributor.author | Wong, FL | en_US |
| dc.contributor.author | Boo, N | en_US |
| dc.contributor.author | Othman, A | en_US |
| dc.date.accessioned | 2024-05-29T03:26:24Z | |
| dc.date.available | 2024-05-29T03:26:24Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | Methods: A prospective study was conducted to investigate the effects of glucose-6-phosphate dehydrogenase (G6PD) mutation, variant uridine diphosphate glucuronosyltransferase UGT1A1 gene and hepatic organic anion transporter protein (OATP2) gene on a group of neonates. Hyperbilirubinemia was defined as a total serum bilirubin level of epsilon 250 mu mol/l. Results: Of 318 neonates, 52 (16.4%) had hyperbilirubinemia. The incidence of G6PD mutation was 5.4% (15/280) among these infants. The incidence of G6PD mutation was significantly higher in the male neonates with hyperbilirubinemia (7.8%) when compared with the normal male neonates without hyperbilirubinemia (1.8%; p = 0.03). Logistic regression analysis showed that the significant risk factors for neonatal hyperbilirubinemia were Malay ethnicity [adjusted odds ratio (OR), 2.77; 95% confidence interval (CI): 1.31-5.86; p = 0.007] and G6PD mutation (adjusted OR, 3.29; 95% CI: 1.06-10.1820; p = 0.039). The gender, birth weight and gestation age of neonates, variant c.211G > A and variant of OATP2 gene were not significant. Conclusions: Neonates with Malay ethnicity and G6PD mutation were at risk for hyperbilirubinemia. | |
| dc.identifier.doi | 10.1093/tropej/fmt023 | |
| dc.identifier.epage | 285 | |
| dc.identifier.issn | 0142-6338 | |
| dc.identifier.issue | 4 | |
| dc.identifier.scopus | WOS:000322665200005 | |
| dc.identifier.spage | 280 | |
| dc.identifier.uri | https://oarep.usim.edu.my/handle/123456789/12109 | |
| dc.identifier.volume | 59 | |
| dc.language | English | |
| dc.language.iso | en_US | |
| dc.publisher | Oxford Univ Press | en_US |
| dc.relation.ispartof | Journal Of Tropical Pediatrics | |
| dc.source | Web Of Science (ISI) | |
| dc.subject | neonatal hyperbilirubinemia | en_US |
| dc.subject | G6PD mutation | en_US |
| dc.subject | OATP2 | en_US |
| dc.subject | UGT1A1 c | en_US |
| dc.subject | 211G > A | en_US |
| dc.title | Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates | |
| dc.type | Article | en_US |
| dspace.entity.type | Publication |