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Evaluation of Drop Volume Consistency of Eyedrop Bottles for New Generic Prostaglandin Analogue, Latanost® in Glaucoma Treatment

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dc.contributor.authorJessica S. C. Ngen_US
dc.contributor.authorYi X. Tanen_US
dc.contributor.authorNor A. A. Alwien_US
dc.contributor.authorKar M. Yeeen_US
dc.contributor.authorAhmad H. A. Rashiden_US
dc.contributor.authorKa-Liong Tanen_US
dc.contributor.authorChuei W. Leongen_US
dc.date.accessioned2024-05-29T01:55:30Z
dc.date.available2024-05-29T01:55:30Z
dc.date.issued2022
dc.date.submitted2023-2-9
dc.descriptionVolume: 12 Issue: 2 (page: 476-480)en_US
dc.description.abstractDifficulty in instilling eyedrop is a concern for it may cause a progression of blindness in glaucoma patients. Early depletion of eyedrop before the next scheduled medication refill is a common issue faced by patients, resulting in poorer compliance to the therapy. Hence, we hypothesize that the lack of drop volume consistency is due to the eye drop bottle-related mechanics during drop instillation. This study aims to select the best bottle designs by examining drop volume consistency during drop instillation. Ten eyedrop bottles of different volumes were filled with 2.5 mL purified water. Next, the drop uniformity test was performed by expelling 10 droplets by holding the bottle vertically and weighing with an analytical balance. Based on the outcome, bottle C, which demonstrated high drop consistency with low percentage standard deviation and near-linear regression, was chosen as the eyedrop container for Latanost® 0.005% w/v eye drops. Using bottle C, the drop volume of Latanost® was estimated at 25.30 ± 1.87 μL. A 2.5 mL latanoprost solution can yield approximately 99.36 ± 7.52 drops per bottle. Besides that, the design of the eyedrop nozzle could determine the consistency of medication delivery. This report could better inform prescribers and patients in predicting the course of treatment. The selection of the right design of container closure system with a consistent drop delivery could significantly address the issue of early depletion of eyedrop before the next scheduled medication refill and difficulty in instilling eyedrop in glaucoma patients. This helps to improve medical treatment compliance in glaucoma patientsen_US
dc.identifier.citationNg JSC, Tan YX, Ahmad Alwi NA, Yee KM, Abdul Rashid AH, Tan K-L, Leong CW. Evaluation of Drop Volume Consistency of Eyedrop Bottles for New Generic Prostaglandin Analogue, Latanost® in Glaucoma Treatment. International Journal of Drug Delivery Technology. 2022;12(2):476-480.en_US
dc.identifier.doi10.25258/ijddt.12.2.3
dc.identifier.epage480
dc.identifier.issn0975-4415
dc.identifier.issue2
dc.identifier.spage476
dc.identifier.urihttp://impactfactor.org/PDF/IJDDT/12/IJDDT,Vol12,Issue2,Article3.pdf
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85134019485&origin=resultslist&sort=plf-f&src=s&sid=3c6fb43e6ebe881c30216628f03f72ed&sot=b&sdt=b&s=TITLE-ABS-KEY%28Evaluation+Of+Drop+Volume+Consistency+Of+Eyedrop+Bottles+For+New+Generic+Prostaglandin+Analogue%2C+Latanost%C2%AE+In+Glaucoma+Treatment%29&sl=180&sessionSearchId=3c6fb43e6ebe881c30216628f03f72ed
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9711
dc.identifier.volume12
dc.language.isoen_USen_US
dc.publisherDr. Yashwant Research Labs Pvt. Ltden_US
dc.relation.ispartofInternational Journal of Drug Delivery Technology (IJDDT)en_US
dc.subjectDrop volume consistency, Glaucoma treatment, Medication adherence, Prostaglandin analogen_US
dc.titleEvaluation of Drop Volume Consistency of Eyedrop Bottles for New Generic Prostaglandin Analogue, Latanost® in Glaucoma Treatmenten_US
dc.typeArticleen_US
dspace.entity.typePublication

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