Publication:
Study On Anti-quorum Sensing Potential Of Selected Local Ulam In Malaysia

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dc.contributor.authorNur Aishah Abdul Wahaben_US
dc.contributor.authorMohd Syazwan Mohd Zainen_US
dc.contributor.authorJalil Kaderen_US
dc.contributor.authorSalina Mat Radzien_US
dc.contributor.authorHanina Mohd Nooren_US
dc.date.accessioned2024-05-27T14:55:08Z
dc.date.available2024-05-27T14:55:08Z
dc.date.issued2014
dc.description.abstractBacterial intercellular communication, or quorum sensing (QS), controls the pathogenesis of many medically important organisms. Anti-QS compounds have the ability to attenuate bacterial pathogenicity. The current quest for new antimicrobials aimed at discovering non-toxic inhibitors of QS from natural sources which can be used for the treatment of bacterial infections in human. The objective of this research is to study the anti-QS potential in some of local ulam commonly found in Malaysia. In this study, seven types of local ulam namely; Parkia speciosa, Cosmos cardatus, Centella asiatica, Manihot esculenta leaf sprigs, Psophocarpus tetragonolobus, Polygonum minus and Oenanthe javanica were tested on the anti-QS potentials in fresh (edible or macerated) forms and methanol extracts via biomonitor strain Chromabacterium violaceum ATCC 12472. This biomonitor strain has an ability to produce a purple pigment (violacein) under QS-control. The results exhibited the wide variation in the anti-QS activities on selected local ulam in fresh and methanol extract forms. The highest anti-QS activity was recorded by P. minus and C. asiatica extracts as the lowest of minimum QS inhibition concentration value (7.81 mg/ml) was indicated by both extracts respectively. This study introduces not only a new mode of action and possible validation for traditional plant use, but also a potentially new therapeutic direction for the treatment of bacterial infections.en_US
dc.identifier.epage211
dc.identifier.issn22784357
dc.identifier.issue3
dc.identifier.other849-28
dc.identifier.spage203
dc.identifier.urihttps://www.wjpps.com/Wjpps_controller/abstract_id/956
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/3945
dc.identifier.volume3
dc.language.isoenen_US
dc.publisherWorld Journal of Pharmacy and Pharmaceutical Sciencesen_US
dc.relation.ispartofWorld Journal of Pharmacy and Pharmaceutical Sciencesen_US
dc.subjectUlam,en_US
dc.subjectChromabacterium violaceum ATCC 12472,en_US
dc.subjectanti-quorum sensingen_US
dc.titleStudy On Anti-quorum Sensing Potential Of Selected Local Ulam In Malaysiaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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