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Neural alterations in working memory of mild-moderate TBI: An fMRI study in Malaysia

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dc.contributor.authorWen Jia Chaien_US
dc.contributor.authorAini Ismafairus Abd Hamiden_US
dc.contributor.authorHazim Omaren_US
dc.contributor.authorMuhammad Riddha Abdul Rahmanen_US
dc.contributor.authorDiana Noma Fitzrolen_US
dc.contributor.authorZamzuri Idrisen_US
dc.contributor.authorAbdul Rahman Izaini Ghanien_US
dc.contributor.authorWan Nor Azlen Wan Mohamaden_US
dc.contributor.authorFaiz Mustafaren_US
dc.contributor.authorMuhammad Hafiz Hanafien_US
dc.contributor.authorRegunath Kandasamyen_US
dc.contributor.authorMohd Zaid Abdullahen_US
dc.contributor.authorKannapha Amaruchkulen_US
dc.contributor.authorPedro A Valdes-Sosaen_US
dc.contributor.authorMaria L Bringas-Vegaen_US
dc.contributor.authorBharat Biswalen_US
dc.contributor.authorJitkomut Songsirien_US
dc.contributor.authorHamwira Yaacoben_US
dc.contributor.authorHaidi Ibrahimen_US
dc.contributor.authorPutra Sumarien_US
dc.date.accessioned2024-05-29T02:26:23Z
dc.date.available2024-05-29T02:26:23Z
dc.date.issued2022
dc.date.submitted2022-4-29
dc.descriptionJournal of Neuroscience ResearchVolume 100, Issue 4 p. 915-932en_US
dc.description.abstractWorking memory (WM) encompasses crucial cognitive processes or abilities to retain and manipulate temporary information for immediate execution of complex cognitive tasks in daily functioning such as reasoning and decision-making. The WM of individuals sustaining traumatic brain injury (TBI) was commonly compromised, especially in the domain of WM. The current study investigated the brain responses of WM in a group of participants with mild–moderate TBI compared to their healthy counterparts employing functional magnetic resonance imaging. All consented participants (healthy: n = 26 and TBI: n = 15) performed two variations of the n-back WM task with four load conditions (0-, 1-, 2-, and 3-back). The respective within-group effects showed a right hemisphere-dominance activation and slower reaction in performance for the TBI group. Random-effects analysis revealed activation difference between the two groups in the right occipital lobe in the guided n-back with cues, and in the bilateral occipital lobe, superior parietal region, and cingulate cortices in the n-back without cues. The left middle frontal gyrus was implicated in the load-dependent processing of WM in both groups. Further group analysis identified that the notable activation changes in the frontal gyri and anterior cingulate cortex are according to low and high loads. Though relatively smaller in scale, this study was eminent as it clarified the neural alterations in WM in the mild–moderate TBI group compared to healthy controls. It confirmed the robustness of the phenomenon in TBI with the reproducibility of the results in a heterogeneous non-Western sample.en_US
dc.identifier.citationChai, W. J., Abd Hamid, A. I., Omar, H., Abdul Rahman, M. R., Fitzrol, D. N., Idris, Z., Ghani, A. R., Wan Mohamad, W. N., Mustafar, F., Hanafi, M. H., Kandasamy, R., Abdullah, M. Z., Amaruchkul, K., Valdes-Sosa, P. A., Bringas-Vega, M. L., Biswal, B., Songsiri, J., Yaacob, H., Ibrahim, H., Sumari, P., Noh, N. A., Musa, K. I., Ahmad, A. H., Azman, A., Jamir Singh, P. S., Othman, A. & Abdullah, J. M. (2022). Neural alterations in working memory of mild-moderate TBI: An fMRI study in Malaysia. Journal of Neuroscience Research, 100, 915– 932. https://doi.org/10.1002/jnr.25023en_US
dc.identifier.doi10.1002/jnr.25023
dc.identifier.epage932
dc.identifier.issn0360-4012
dc.identifier.issue2022
dc.identifier.other823-28
dc.identifier.spage915
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/jnr.25023
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10599
dc.identifier.volume4
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJournal of Neuroscience Researchen_US
dc.titleNeural alterations in working memory of mild-moderate TBI: An fMRI study in Malaysiaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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