Publication:
Fatal infections in older patients with inflammatory bowel disease on anti-tumor necrosis factor therapy

Simple item page
dc.citedby2
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversity of Malaya (UM)
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorLee W.-S.en_US
dc.contributor.authorAzmi N.en_US
dc.contributor.authorNg R.-T.en_US
dc.contributor.authorOng S.-Y.en_US
dc.contributor.authorPonnampalavanar S.S.L.en_US
dc.contributor.authorMahadeva S.en_US
dc.contributor.authorHilmi I.en_US
dc.date.accessioned2024-05-28T08:24:53Z
dc.date.available2024-05-28T08:24:53Z
dc.date.issued2017
dc.description.abstractAnti-tumor necrosis factor (anti-TNF) is highly effective in inflammatory bowel disease (IBD); however, it is associated with an increased risk of infections, particularly in older adults. We reviewed 349 patients with IBD, who were observed over a 12-month period, 74 of whom had received anti-TNF therapy (71 patients were aged < 60 years and 3 were aged ?60 years). All the 3 older patients developed serious infectious complications after receiving anti-TNFs, although all of them were also on concomitant immunosuppressive therapy. One patient developed disseminated tuberculosis, another patient developed cholera diarrhea followed by nosocomial pneumonia, while the third patient developed multiple opportunistic infections (Pneumocystis pneumonia, cryptococcal septicemia and meningitis, Klebsiella septicemia). All 3 patients died within 1 year from the onset of the infection(s). We recommend that anti-TNF, especially when combined with other immunosuppressive therapy, should be used with extreme caution in older adult patients with IBD. � 2017. Korean Association for the Study of Intestinal Diseases.
dc.description.natureFinalen_US
dc.identifier.doi10.5217/ir.2017.15.4.524
dc.identifier.epage528
dc.identifier.issn15989100
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85031916540
dc.identifier.spage524
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85031916540&doi=10.5217%2fir.2017.15.4.524&partnerID=40&md5=5b7e51e3077beecf0efba1cade528d60
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8577
dc.identifier.volume15
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherKorean Association for the Study of Intestinal Diseasesen_US
dc.relation.ispartofIntestinal Research
dc.sourceScopus
dc.subjectAnti-tumor necrosis factoren_US
dc.subjectElderly patientsen_US
dc.subjectSerious infectionsen_US
dc.titleFatal infections in older patients with inflammatory bowel disease on anti-tumor necrosis factor therapyen_US
dc.title.alternativeIntest. Res.en_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Fatal infections in older patients with inflammatory bowel disease on anti-tumor necrosis factor therapy.pdf
Size:
723.45 KB
Format:
Adobe Portable Document Format
Download

Collections

Scopus