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Topological characterization of a bacterial cellulose-acrylic acid polymeric matrix

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dc.contributor.authorN. Haliben_US
dc.contributor.authorAmin, MCIMen_US
dc.contributor.authorAhmad, Ien_US
dc.contributor.authorAbrami, Men_US
dc.contributor.authorFiorentino, Sen_US
dc.contributor.authorFarra, Ren_US
dc.contributor.authorGrassi, Gen_US
dc.contributor.authorMusiani, Fen_US
dc.contributor.authorLapasin, Ren_US
dc.contributor.authorGrassi, Men_US
dc.date.accessioned2024-05-29T02:51:05Z
dc.date.available2024-05-29T02:51:05Z
dc.date.issued2014
dc.description.abstractThis paper focuses on the micro- and nano-topological organization of a hydrogel, constituted by a mixture of bacterial cellulose and acrylic acid, and intended for biomedical applications. The presence of acrylic acid promotes the formation of two interpenetrated continuous phases: the primary "pores phase" (PP) containing only water and the secondary "polymeric network phase" (PNP) constituted by the polymeric network swollen by the water. Low field Nuclear Magnetic Resonance (LF NMR), rheology, Scanning Electron Microscopy (SEM) and release tests were used to determine the characteristics of the two phases. In particular, we found that this system is a strong hydrogel constituted by 81% (v/v) of PP phase the remaining part being occupied by the PNP phase. Pores diameters span in the range 10-100 pm, the majority of them (85%) falling in the range 30-90 mu m. The high PP phase tortuosity indicates that big pores are not directly connected to each other, but their connection is realized by a series of interconnected small pores that rend the drug path tortuous. The PNP is characterized by a polymer volume fraction around 0.73 while mesh size is around 3 nm. The theoretical interpretation of the experimental data coming from the techniques panel adopted, yielded to the micro- and nano-organization of our hydrogel. (C) 2014 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.ejps.2014.06.004
dc.identifier.epage333
dc.identifier.issn0928-0987
dc.identifier.scopusWOS:000340301500038
dc.identifier.spage326
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11150
dc.identifier.volume62
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal Of Pharmaceutical Sciences
dc.sourceWeb Of Science (ISI)
dc.subjectLow field NMRen_US
dc.subjectRheologyen_US
dc.subjectDrug releaseen_US
dc.subjectMesh-sizeen_US
dc.subjectPorous gelsen_US
dc.titleTopological characterization of a bacterial cellulose-acrylic acid polymeric matrixen_US
dc.typeArticleen_US
dspace.entity.typePublication

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