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Posterior reversible encephalopathy syndrome in systemic lupus erythematosus: Pooled analysis of the literature reviews and report of six new cases

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dc.Chemicals/CAScyclosporin A, 59865-13-3, 63798-73-2; mycophenolic acid 2 morpholinoethyl ester, 116680-01-4, 128794-94-5; prednisolone, 50-24-8
dc.citedby23
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM) Medical Centre
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorShaharir S.S.en_US
dc.contributor.authorRemli R.en_US
dc.contributor.authorMarwan A.A.en_US
dc.contributor.authorSaid M.S.M.en_US
dc.contributor.authorKong N.C.T.en_US
dc.date.accessioned2024-05-29T01:59:33Z
dc.date.available2024-05-29T01:59:33Z
dc.date.issued2013
dc.description.abstractIntroduction: Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disorder which is increasingly recognized to occur in systemic lupus erythematosus (SLE). Objective: The purpose of this study was to identify the characteristics of SLE patients with PRES and the associated factors of the poor outcome among them. Methods: We investigated SLE patients who developed PRES between 2005-2011 at the Universiti Kebangsaan Malaysia Medical Centre. A comprehensive literature search was done to find all published cases of PRES in SLE. Pooled analysis was conducted to identify the factors associated with poor outcome. Results: There were 103 cases of PRES in SLE published in the literature but only 87 cases were included in the analysis in view of incomplete individual data in the remaining cases. The majority of the cases were Asians (74.2%), female (95.4%) with mean age of 26.3±8.8 years. PRES was highly associated with active disease (97.5%), hypertension (91.7%) and renal involvement (85.1%). We found that 79 patients had a full recovery (90.8%) with a mean onset of full clinical recovery in 5.6±4.1 days. On univariate analysis and logistic regression analysis the predictors of poor outcome, defined as incomplete clinical recovery or death, were intracranial hemorrhage, odds ratio (OR) 14 (1.1-187.2), p=0.04 and brainstem involvement in PRES, OR 10.9 (1.3-90.6), p=0.003. Conclusion: Intracranial hemorrhage and brainstem involvement were the two important predictors of poor outcome of PRES. Larger prospective studies are needed to further delineate the risk of poor outcome among them.en_US
dc.description.natureFinalen_US
dc.identifier.CODENLUPUE
dc.identifier.doi10.1177/0961203313478303
dc.identifier.epage496
dc.identifier.issn9612033
dc.identifier.issue5
dc.identifier.pmid23435619
dc.identifier.scopus2-s2.0-84875914256
dc.identifier.spage492
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84875914256&doi=10.1177%2f0961203313478303&partnerID=40&md5=2673b8303bbf0a53842294c3dd428fbf
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10068
dc.identifier.volume22
dc.languageEnglish
dc.language.isoen_USen_US
dc.relation.ispartofLupus
dc.sourceScopus
dc.subjecthemorrhageen_US
dc.subjectlupusen_US
dc.subjectPosterior reversible encephalopathy syndromeen_US
dc.subjectrenalen_US
dc.titlePosterior reversible encephalopathy syndrome in systemic lupus erythematosus: Pooled analysis of the literature reviews and report of six new casesen_US
dc.title.alternativeLupusen_US
dc.typeArticleen_US
dspace.entity.typePublication

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