Publication:
Antibacterial Activity Of Spilanthes Acmella Flower Extracts (safe) Against Streptococcus Mutans

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dc.contributor.authorSiti Aisyah Abd Ghafaren_US
dc.contributor.authorMuhammad Fikhry Mohd Salehuddin,en_US
dc.contributor.authorNur Syamimi Syuhada Che Awangen_US
dc.contributor.authorRohazila Mohamad Hanafiahen_US
dc.date.accessioned2024-05-28T03:29:58Z
dc.date.available2024-05-28T03:29:58Z
dc.date.issued2019
dc.date.submitted29/1/2020
dc.descriptionMalaysian Journal of Medicine and Health Sciences, 2019;15(108):42-42.en_US
dc.description.abstractIntroduction:Spilanthes acmella, also known as “subang nenek’, has been used traditionally in Malaysia to treat toothache. A previous study has shown Spilanthes acmella leaves extracts (SALE) inhibit Streptococcus mutans growth. Streptococcus mutans is commonly found in the human oral cavity and is the main contributor to tooth de-cay. There is no study on the antibacterial effects of Spilanthes acmella flower extracts (SAFE) against Streptococcus mutans reported to date. Therefore, the objective of this study is to investigate antibacterial properties of SAFE against S. mutans. Methods:S. mutans was subcultured in Muller Hinton (MH) broth and agar. Sequential extractions of S. acmella flowers were conducted using four different solvents with increasing polarity, [n- hexane, dichloromethane (DCM), acetone, methanol (MeoH)] and tested with different concentrations against S. mutans via the disc diffusion assay, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). Sodium fluoride (NaF) was used as a positive control while DMSO was used as a negative control. Results: The disc diffusion assay shows SAFE inhibited Streptococcus mutans growth. SAFE-DCM shows the greatest inhibition properties (12.33±2.30 mm) followed by SAFE-n-hexane (11.33±0.57 mm). Meanwhile, SAFE-Meoh and SAFE-acetone show no inhibition zone (6.00±0.001 mm). MIC value for SAFE-DCM and SAFE-n-hexane is 12.5 mg/mL respectively. Whereas, MBC value SAFE-DCM and SAFE-n-hexane is 50.0 mg/mL respectively. Conclusion: It can be concluded SAFE-DCM and SAFE-n-hexane possesses bactericidal properties against Streptococcus mutans.en_US
dc.identifier.epage0
dc.identifier.issn1675-8544
dc.identifier.issue8
dc.identifier.other1815-18
dc.identifier.spage42
dc.identifier.urihttp://mymedr.afpm.org.my/publications/84837
dc.identifier.urichrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/viewer.html?pdfurl=https%3A%2F%2Fmedic.upm.edu.my%2Fupload%2Fdokumen%2F20191129102937Complete_file_2nd_ICOMOI_2019.pdf&clen=294332&chunk=true
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/4486
dc.identifier.volume15
dc.language.isoenen_US
dc.publisherUPMen_US
dc.relation.ispartofMalaysian Journal of Medicine and Health Sciencesen_US
dc.titleAntibacterial Activity Of Spilanthes Acmella Flower Extracts (safe) Against Streptococcus Mutansen_US
dc.typeArticleen_US
dspace.entity.typePublication

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