Publication:
Vancomycin resistant Enterococcus (VRE): Prevalence and characteristics in a tertiary hospital in Malaysia

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dc.citedby1
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsHospital Ampang
dc.contributor.affiliationsInstitute of Medical Research
dc.contributor.authorMohamed N.A.en_US
dc.contributor.authorHussin H.en_US
dc.contributor.authorChang K.M.en_US
dc.contributor.authorHashim R.en_US
dc.contributor.authorAhmad N.en_US
dc.date.accessioned2024-05-29T01:58:06Z
dc.date.available2024-05-29T01:58:06Z
dc.date.issued2015
dc.description.abstractIntroduction: Vancomycin-resistant Enterococcus (VRE) are undoubtedly less virulent as compared to other common pathogenic bacteria such as Staphylococcus aureus. However the presence of VRE is a matter of concern, as VRE infections are associated with high mortality, particularly in immunocompromised patients. The resistant gene is transferable to Methicillin-Resistant Staphylococcus aureus (MRSA). Materials and Methods: VRE cases from clinical samples in a tertiary government hospital were identified retrospectively over a period of 12 months. VRE genotype was confirmed by molecular method. Patients' clinical data were obtained from the hospital information system. Results: 2.88% (n=7/243) of all Enterococcal spp isolated from clinical samples were resistant to vancomycin (VRE). All were from haematological patients, six were diagnosed with neutropaenic sepsis. All VRE were isolated within eight to 37 days after chemotherapy. Six out of seven cases where VRE were isolated had received carbapenem in their therapy. There were four samples from central venous catheter, one from peripheral blood, one from pus and one from urine sample. Only three patients were treated with Linezolid. However, all patients recovered well. All isolates carry vanA gene with vancomycin MIC of > 256 ug/mL. Conclusions: The prevalence of VRE in this current study is higher than an earlier study done in Malaysia. This finding showed that patients from haematological ward had higher risk of VRE colonization or infection. Periodic screening is necessary to monitor the prevalence of multidrug resistant organism in order to encourage healthcare workers towards practicing proper infection control measures.en_US
dc.description.natureFinalen_US
dc.identifier.epage246
dc.identifier.issn15605876
dc.identifier.issue5
dc.identifier.scopus2-s2.0-84963800322
dc.identifier.spage241
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84963800322&partnerID=40&md5=4144175ef28fc42121900887e9a48caa
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9976
dc.identifier.volume11
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherMinistry of Healthen_US
dc.relation.ispartofBrunei International Medical Journalen_US
dc.sourceScopus
dc.subjectHaematologyen_US
dc.subjectMicrobial resistanceen_US
dc.subjectPrevalenceen_US
dc.subjectSepsisen_US
dc.subjectVancomycin-resistant Enterococcusen_US
dc.titleVancomycin resistant Enterococcus (VRE): Prevalence and characteristics in a tertiary hospital in Malaysiaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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