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Early Viral Clearance Among Covid-19 Patients When Gargling With Povidone-iodine And Essential Oils: A Clinical Trial

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dc.contributor.authorNurul Azmawati Mohameden_US
dc.contributor.authorNizam Baharomen_US
dc.contributor.authorWan Shahida Wan Sulaimanen_US
dc.contributor.authorZetti Zainol Rashiden_US
dc.contributor.authorWong Kon Kenen_US
dc.contributor.authorUmi Kalsom Alien_US
dc.contributor.authorSiti Norlia Othmanen_US
dc.contributor.authorMuttaqillah Najihan Samaten_US
dc.contributor.authorNajma Korien_US
dc.contributor.authorPetrick Periyasamyen_US
dc.contributor.authorNor Azizan Zakariaen_US
dc.contributor.authorAgni Nhirmal Kumar Sugurmaren_US
dc.contributor.authorNur Ezzaty Mohammad Kazminen_US
dc.contributor.authorCheong Xiong Kheeen_US
dc.contributor.authorSiti Mariyam Sanimanen_US
dc.contributor.authorIlina Isahaken_US
dc.date.accessioned2024-05-28T04:44:22Z
dc.date.available2024-05-28T04:44:22Z
dc.date.issued2020
dc.date.submitted44348
dc.descriptionInternational Medical Journal Vol. 27, No. 6, pp. 651 - 654 , December 2020en_US
dc.description.abstractBackground: Gargling had been reported to have significant roles in the prevention and treatment of respiratory tract infections. The purpose of this study was to assess the ability of regular gargling to eliminate SARS-CoV-2 in the oropharynx and nasopharynx. Methodology: This pilot, open labeled, randomized, parallel study compared the effect of 30 seconds, 3 times/day gargling using 1% povidone-iodine (PVP-I), essential oils and tap water on SARS-CoV-2 viral clearance among COVID-19 patients in a tertiary hospital in Kuala Lumpur. Progress was monitored by day 4,6 and 12 PCR (Ct value), gargling and symptoms diary as well as clinical observations. Results: Five confirmed Stage 1 COVID-19 patients were recruited for each arm. The age range was from 22 to 56 years old. The majority were males. Two respondents had co-morbidities, which were asthma and obesity. Viral clearance was achieved at day 6 in 100%, 80%, 20% and 0% for 1% PVP-I, essential oils, tap water and control group respectively. Analysis of 1% PVP-I group versus control group showed significant p-value for comparison of PCR results on Day 4, Day 6 and Day 12. Conclusions: This preliminary study showed that gargling with 1% PVP-I and essential oils show great potential to be part of the treatment and management of Stage 1 COVID-19. Larger studies are required to ascertain the benefit of gargling for different stages of COVID-19 patients. This study was registered in clinicaltrial.gov (NCT04410159).en_US
dc.identifier.citationMohamed, Nurul & Shahida, Wan & Sulaiman, Wan & Zetti, Zainol & Rashid, Zetti & Kon Ken, Wong & Ken, & Umi, Kalsom & Ali, Umi & Siti, Norlia & Othman, & Abdul Samat, Muttaqillah & Kori, Najma & Periyasamy, Petrick & Zakaria, Azizan & Nhirmal, Agni & Sugurmar, Kumar & Ezzaty, Nur & Mohammad Kazmin, Nur Ezzaty & Isahak, Ilina. (2020). Early Viral Clearance among COVID-19 Patients When Gargling with Povidone-Iodine and Essential Oils: A Clinical Trial. International Medical Journal (1994). 27. 651-654.en_US
dc.identifier.doihttps://doi.org/10.1101/2020.09.07.20180448
dc.identifier.epage654
dc.identifier.issn1341-2051
dc.identifier.issue6
dc.identifier.spage651
dc.identifier.urihttps://www.medrxiv.org/content/10.1101/2020.09.07.20180448v1
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/6116
dc.identifier.volume27
dc.language.isoen_USen_US
dc.publisherJapan Health Sciences Universityen_US
dc.relation.ispartofInternational Medical Journalen_US
dc.subjectgargle,en_US
dc.subjectpovidone-iodine,en_US
dc.subjectPVP-I,en_US
dc.subjectessential oils,en_US
dc.subjectCOVID-19en_US
dc.titleEarly Viral Clearance Among Covid-19 Patients When Gargling With Povidone-iodine And Essential Oils: A Clinical Trialen_US
dc.typeArticleen_US
dspace.entity.typePublication

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