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Effects of Sargassumoligocystum and Padina australis extract on Adipogenesis and Adipolysis in 3T3-L1 Cells

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dc.contributor.authorJaswir, Ien_US
dc.contributor.authorAhmad, Hen_US
dc.contributor.authorSusanti, Den_US
dc.contributor.authorBakhtiar, MTen_US
dc.contributor.authorOctavianti, Fen_US
dc.date.accessioned2024-05-29T02:52:52Z
dc.date.available2024-05-29T02:52:52Z
dc.date.issued2017
dc.description.abstractIn recent years, the search for natural, safe and effective therapies for the management of obesity has become important. The present study investigated the potential of brown seaweeds Sargassum oligocystum and Padina australis from Malaysian waters as natural alternatives for the management of obesity. Both seaweeds were macerated using acetone at room temperature for ten hours. The S. oligocystum extracts (SE) and P. australis extracts (PE) were then applied to 3T3-L1 cells during the differentiation stage and during the mature stage of the adipocyte life cycle to assess the effects of extracts on adipogenesis and adipolysis. Application of SE at 12.5 and 50 mu g/ml to the cells decreased adipogenesis by 71.7%, and 84.8%, respectively, while cells treated with 12.5 and 50 mu g/ml PE showed 85.7%, and 89.0% adipogenesis respectively, compared to control. Application of SE and PE to mature lipid cells stimulated adipolysis and the release of glycerol into the culture media. Application of SE at 12.5 and 50 mu g mu g/ml in the cell media induced glycerol release by up to 88.6 and 93.0%, respectively, while PE increased glycerol release up to 92.9 and 95.6% respectively, compared to isoproterenol. This study demonstrates the potential of whole brown seaweed extracts from S. oligocystum and P. australis collected from Malaysian waters as natural anti-obesity agents. Incorporation of the brown seaweed into the diet as a functional food will be useful for prevention and treatment of obesity. (C) All Rights Reserved
dc.identifier.epageS401
dc.identifier.isbn2231-7546
dc.identifier.issn1985-4668
dc.identifier.scopusWOS:000432396300020
dc.identifier.spageS395
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11344
dc.identifier.volume24
dc.languageEnglish
dc.language.isoen_US
dc.publisherUniv Putra Malaysia Pressen_US
dc.relation.ispartofInternational Food Research Journal
dc.sourceWeb Of Science (ISI)
dc.subjectAdipogenesisen_US
dc.subjectAdipolysisen_US
dc.subjectBrown seaweedsen_US
dc.subjectExtractionen_US
dc.titleEffects of Sargassumoligocystum and Padina australis extract on Adipogenesis and Adipolysis in 3T3-L1 Cells
dc.typeArticleen_US
dspace.entity.typePublication

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