Publication:
Oro-pharyngeal carriage and antimicrobial susceptibility of streptococcus pneumoniae from healthy children

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dc.Chemicals/CASazithromycin, 83905-01-5; ceftriaxone, 73384-59-5, 74578-69-1; erythromycin, 114-07-8, 70536-18-4; vancomycin, 1404-90-6, 1404-93-9
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorRashid Z.Z.en_US
dc.contributor.authorIsahak I.en_US
dc.contributor.authorChiam P.J.en_US
dc.contributor.authorSuki M.H.en_US
dc.contributor.authorMohamad N.A.en_US
dc.contributor.authorHussain D.en_US
dc.contributor.authorSim T.Y.en_US
dc.contributor.authorJaafar H.M.en_US
dc.contributor.authorYusof Y.A.M.en_US
dc.contributor.authorRahman M.M.en_US
dc.date.accessioned2024-05-29T01:59:54Z
dc.date.available2024-05-29T01:59:54Z
dc.date.issued2013
dc.description.abstractObjectives: Streptococcus pneumoniae causes acute otitis media, pneumonia, meningitis and bacteraemia. This study aimed to determine the prevalence of Streptococcus pneumoniae oropharyngeal carriage in healthy children and the antimicrobial susceptibility in a daycare nursery and a government-managed orphanage in Kuala Lumpur during 2010.Methods: Throat swabs were obtained from 36 children of daycare nursery (open community) and from 84 orphans from orphanage (closed community) those did not receive any pneumococcal vaccine. Children were between births to 6 years of age. Antibiotic susceptibility of isolated strains was determined using disk diffusion method and Etest� (minimum inhibitory concentration). Results: Overall prevalence of Streptococcus pneumoniae of the children was 1.7% (2 out of 120). Prevalence of the bacteria in open community was 5.6% (2 out of 36) and no positive cases were recorded in orphanage (closed community, (p=0.161). Prevalence was 15.4% (2 out of 13) in children aged below 2 years in the open community. There was no association was found to exist between Streptococcus pneumoniae carriage with age (p=0.432) and gender (p=0.418). Serotyping showed serotype 11F for one isolate, while the other was non-typable. Both isolates were susceptible to penicillin, azithromycin, ceftriaxone and vancomycin. The serotype 11F isolate was susceptible while the non-typable isolate was resistant to erythromycin.Conclusions: The results demonstrated low prevalence of Streptococcus pneumoniae in healthy children. These findings may complement other studies to explore further risk factors for colonisation, antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae to help for the planning of immunization strategies.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.5580/2cda
dc.identifier.issn19378289
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84874400405
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84874400405&doi=10.5580%2f2cda&partnerID=40&md5=6215d9122b8374c2401323801f9f3472
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10091
dc.identifier.volume11
dc.languageEnglish
dc.language.isoen_USen_US
dc.relation.ispartofInternet Journal of Microbiology
dc.sourceScopus
dc.subjectAntimicrobial susceptibilityen_US
dc.subjectChildrenen_US
dc.subjectColonisationen_US
dc.subjectOropharyngeal carriageen_US
dc.subjectSerotypeen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.titleOro-pharyngeal carriage and antimicrobial susceptibility of streptococcus pneumoniae from healthy childrenen_US
dc.title.alternativeInternet J. Microbiol.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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