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Apolipoprotein E gene polymorphisms in essential hypertension: A preliminary study with meta-analysis

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dc.citedby2
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsInternational Islamic University Malaysia (IIUM)
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorWisam N.I.en_US
dc.contributor.authorNorsidah K.Z.en_US
dc.contributor.authorSamsul D.en_US
dc.contributor.authorZamzila A.en_US
dc.contributor.authorRafidah H.M.en_US
dc.contributor.authorNorlelawati A.T.en_US
dc.date.accessioned2024-05-29T01:55:59Z
dc.date.available2024-05-29T01:55:59Z
dc.date.issued2015
dc.description.abstractIntroduction: Essential hypertension is a multifactorial disease. Many experimental studies have elucidated the role of oxidative stress and atherosclerosis in the pathogenesis of essential hypertension. Apolipoprotein E is a plasma protein that is found to have antioxidant properties, and it also protects against atherosclerosis. Interestingly, the biological function of apolipoprotein E is strongly affected by polymorphisms in its gene. Based on this evidence, our aim was to investigate the association of apolipoprotein E gene polymorphisms with essential hypertension. Methods: This study was conducted on 70 hypertensive patients and 73 control participants recruited from the Balok governmental health clinic in Kuantan, Pahang. The polymerase chain reaction restriction fragment length polymorphism assay (PCR-RFLP) was used for determination of the apolipoprotein E genotype. Our results were also verified later by direct sequencing of the amplicons. Results: There was no significant association of apolipoprotein E allele or genotype frequencies with hypertensive disease or blood pressure levels, although the E4 allele was slightly more frequent in the hypertensive patients than in the control group (OR=1.055; 0.471-2.359, CI 95%). To improve the precision of the study and to settle the controversies among similar studies meta-analysis was performed; however it revealed a net nonsignificant association between the apolipoprotein E4 allele with essential hypertension in the combined population. Conclusion: Our data and the meta-analysis findings provide evidence that apolipoprotein E gene polymorphism has no direct significant association with hypertension.
dc.description.natureFinalen_US
dc.identifier.epage52
dc.identifier.issn18234631
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84958162502
dc.identifier.spage45
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84958162502&partnerID=40&md5=071642cf201b825bdc46ce99ca723346
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9782
dc.identifier.volume14
dc.languageEnglish
dc.language.isoen_US
dc.publisherInternational Islamic University Malaysiaen_US
dc.relation.ispartofInternational Medical Journal Malaysia
dc.sourceScopus
dc.subjectApolipoprotein Een_US
dc.subjectEssential hypertensionen_US
dc.subjectSingle nucleotide gene polymorphismen_US
dc.titleApolipoprotein E gene polymorphisms in essential hypertension: A preliminary study with meta-analysis
dc.typeArticleen_US
dspace.entity.typePublication

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