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Retinal Optical Coherence Tomography Angiography Parameters Between Patients With Different Causes Of Chronic Kidney Disease

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dc.contributor.authorMeng Hsien Yongen_US
dc.contributor.authorMing Yean Ongen_US
dc.contributor.authorKuan Sze Tanen_US
dc.contributor.authorSiti Husna Husseinen_US
dc.contributor.authorAyesha Mohd Zainen_US
dc.contributor.authorRozita Mohden_US
dc.contributor.authorRuslinda Mustafaren_US
dc.contributor.authorWan Haslina Wan Abdul Halimen_US
dc.date.accessioned2024-05-29T02:28:56Z
dc.date.available2024-05-29T02:28:56Z
dc.date.issued2022
dc.date.submitted2024-2-6
dc.descriptionFrontiers in Cellular Neuroscience Volume 16 Page (1-8)en_US
dc.description.abstractBackground: Chronic kidney disease (CKD) is a major public health issue because of the rising number of patients with the risk of progression to end-stage renal disease. The retinal micro-vasculatures provide a unique window to assess systemic microcirculation. Optical Coherence Tomography Angiography (OCTA) parameters may provide a noninvasive method for systemic correlation. This research aims to compare the association of OCTA parameters in different causes of CKD. Methods: This is a single-center cross-sectional study on patients with CKD at the Universiti Kebangsaan Malaysia Medical Centre over 2 years. Patients with CKD were divided into three groups: DM group (diabetic CKD), HPT group (hypertensive CKD), and AG group (autoimmune-related glomerulonephritis CKD). The OCTA parameters, namely, the foveal avascular zone (FAZ), vascular density (VD), perfusion density (PD), and macular volume (MV), were measured and recorded using OCTA. Blood and urine analyses were taken as the patient’s CKD profile. The demographic data, the OCTA parameters and the CKD profiles, were analyzed using SPSS version 23. Results: The right eyes of 232 patients were included. The median age of the control and CKD subjects were 36 and 61 years old respectively. The proportion of the subjects under the control, diabetes mellitus (DM), HPT, and AG group were 30.6, 53.4, 5.6, and 10.4% respectively. There was no significant difference in FAZ, but there is a significant difference in the VD, PD, and MV between the control and CKD groups. There was a statistically significant difference between the three different causes of CKD in VD and PD (p < 0.001, p = 0.001, respectively). When compared with the control group for VD and PD, there were significant differences between the DM-control group (p < 0.001, p < 0.001) even when the age variable was considered, but no significant difference when comparing the HPT-control and the AG-control. There was a significant correlation between age, FBS, and HbA1c with VD and PD. There was no significant association between CKD profile and FAZ.Conclusion: Our study showed the meaningful reduction of VD and PD in patients with diabetes and CKD. However, the use of OCTA to screen or predict CKD in patients living with diabetes mellitus, hypertension, or autoimmune nephritis was not shown to be useful.en_US
dc.identifier.citationYong MH, Ong MY, Tan KS, Hussein SH, Mohd Zain A, Mohd R, Mustafar R and Wan Abdul Halim WH (2022) Retinal Optical Coherence Tomography Angiography Parameters Between Patients With Different Causes of Chronic Kidney Disease. Front. Cell. Neurosci. 16:766619. doi: 10.3389/fncel.2022.766619en_US
dc.identifier.doi10.3389/fncel.2022.766619
dc.identifier.epage8
dc.identifier.issn1662-5102
dc.identifier.issueMarch 2022
dc.identifier.spage1
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fncel.2022.766619/full
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10789
dc.identifier.volume16
dc.language.isoenen_US
dc.publisherFrontieren_US
dc.relation.ispartofFrontiers in Cellular Neuroscienceen_US
dc.subjectoptical coherenc tomography angiography, chronic kidney disease, retina, vascular density, perfusion density, macular volume, foveal avascular zoneen_US
dc.titleRetinal Optical Coherence Tomography Angiography Parameters Between Patients With Different Causes Of Chronic Kidney Diseaseen_US
dc.typeArticleen_US
dspace.entity.typePublication

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