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Gene expression profiling of host lipid metabolism in SARS-CoV-2 infected patients: a systematic review and integrated bioinformatics analysis

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dc.contributor.authorWan Amirul Syazwan Wan Ahmad Munawar
dc.contributor.authorMarjanu Hikmah Elias
dc.contributor.authorFaizul Helmi Addnan
dc.contributor.authorPouya Hassandarvish
dc.contributor.authorSazaly AbuBakar
dc.contributor.authorNuruliza Roslan
dc.date.accessioned2024-07-13T15:15:32Z
dc.date.available2024-07-13T15:15:32Z
dc.date.issued2024
dc.date.submitted2024-6-26
dc.descriptionBMC Infectious Diseases, Volume 24 Issue (1)
dc.description.abstractBackground The Coronavirus disease 2019 (COVID-19) pandemic occurred due to the dispersion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severe symptoms can be observed in COVID-19 patients with lipid-related comorbidities such as obesity and diabetes. Yet, the extensive molecular mechanisms of how SARS-CoV-2 causes dysregulation of lipid metabolism remain unknown. Methods Here, an advanced search of articles was conducted using PubMed, Scopus, EBSCOhost, and Web of Science databases using terms from Medical Subject Heading (MeSH) like SARS-CoV-2, lipid metabolism and transcriptomic as the keywords. From 428 retrieved studies, only clinical studies using next-generation sequencing as a gene expression method in COVID-19 patients were accepted. Study design, study population, sample type, the method for gene expression and differentially expressed genes (DEGs) were extracted from the five included studies. The DEGs obtained from the studies were pooled and analyzed using the bioinformatics software package, DAVID, to determine the enriched pathways. The DEGs involved in lipid metabolic pathways were selected and further analyzed using STRING and Cytoscape through visualization by protein-protein interaction (PPI) network complex. Results The analysis identified nine remarkable clusters from the PPI complex, where cluster 1 showed the highest molecular interaction score. Three potential candidate genes (PPARG, IFITM3 and APOBEC3G) were pointed out from the integrated bioinformatics analysis in this systematic review and were chosen due to their significant role in regulating lipid metabolism. These candidate genes were significantly involved in enriched lipid metabolic pathways, mainly in regulating lipid homeostasis affecting the pathogenicity of SARS-CoV-2, specifically in mechanisms of viral entry and viral replication in COVID-19 patients. Conclusions Taken together, our findings in this systematic review highlight the affected lipid-metabolic pathways along with the affected genes upon SARS-CoV-2 invasion, which could be a potential target for new therapeutic strategies study in the future.
dc.identifier.citationWan Amirul Syazwan Wan Ahmad Munawar , Marjanu Hikmah Elias , Faizul Helmi Addnan , Pouya Hassandarvish , Sazaly AbuBakar and Nuruliza Roslan (2024). Gene expression profiling of host lipid metabolism in SARS-CoV-2 infected patients: a systematic review and integrated bioinformatics analysis. BMC Infectious Diseases, 24(1). https://doi.org/10.1186/s12879-024-08983-0
dc.identifier.doi10.1186/s12879-024-08983-0
dc.identifier.epage14
dc.identifier.issn1471-2334
dc.identifier.issue124
dc.identifier.other2160-29
dc.identifier.spage1
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/20613
dc.identifier.volume24
dc.language.isoen_US
dc.publisherBMC
dc.relation.ispartofBMC Infectious Diseases
dc.relation.issn1471-2334
dc.relation.journalBMC Infectious Diseases
dc.subjectSARS-CoV-2
dc.subjectLipid metabolism
dc.subjectGene expression
dc.subjectBioinformatics
dc.subjectNext-generation sequencing
dc.titleGene expression profiling of host lipid metabolism in SARS-CoV-2 infected patients: a systematic review and integrated bioinformatics analysis
dc.typetext::journal::journal article::research article
dspace.entity.typePublication
oaire.citation.endPage14
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.volume24
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliationUniversiti Sains Islam Malaysia

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