Publication:
Improved Skin Wound Healing Activity of Insulin Cream as Evidenced from the Morphological Evaluation in Guinea Pigs

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dc.contributor.authorMohamed, NAHen_US
dc.contributor.authorMokhtar, RHen_US
dc.contributor.authorAl-Ani, IMen_US
dc.contributor.authorAyob, Aen_US
dc.contributor.authorMisran, Men_US
dc.date.accessioned2024-05-29T02:54:17Z
dc.date.available2024-05-29T02:54:17Z
dc.date.issued2018
dc.description.abstractBackground: There is no histological study evaluating the effects of insulin-containing cream on skin injury. The goal of this study was to examine the effects of insulin-containing creams on wound healing. Methods: Creams consisting of nine parts of oil and one part of aqueous phase (9:1) mixed with 1.5 mL human insulin were prepared. Eighteen male guinea pigs were divided into three groups; the control (9:1 C) group received cream without insulin. The experimental groups received Humulin N (9:1 N) and Humulin R (9:1 R) respectively. A 1 cm(2) wound of 1-2 cm thickness was created in the skin. Each animal received 0.5 g of the respective creams which was topically applied once a day for 14 days. The progress of wound healing was monitored daily. Skin tissues were excised at the 14th days from the wound sites and processed for light microscopy. Results: Skin wound treated with the long acting insulin Humulin N had an accelerated wound healing process with restoration of vascular network, increased collagen deposition and early complete wound remodeling. Conclusions: Insulin cream with long acting mechanism facilitates in normalizing cell permeability, promoting vascularization, reducing exudation and stimulate proliferation of cells. These properties render insulin cream suitable for expediting wound healing.
dc.identifier.doi10.7454/msk.v22i2.9714
dc.identifier.epage94
dc.identifier.isbn2356-3656
dc.identifier.issn2356-3664
dc.identifier.issue2
dc.identifier.scopusWOS:000444771200006
dc.identifier.spage88
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11457
dc.identifier.volume22
dc.languageEnglish
dc.language.isoen_US
dc.publisherUniv Indonesiaen_US
dc.relation.ispartofMakara Journal Of Health Research
dc.sourceWeb Of Science (ISI)
dc.subjectinflammationen_US
dc.subjectinsulin creamen_US
dc.subjectGuinea pigsen_US
dc.subjectskinen_US
dc.subjectwound healingen_US
dc.titleImproved Skin Wound Healing Activity of Insulin Cream as Evidenced from the Morphological Evaluation in Guinea Pigs
dc.typeArticleen_US
dspace.entity.typePublication

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