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The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae

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dc.contributor.authorAbu Hasan, ZIen_US
dc.contributor.authorWilliams, Hen_US
dc.contributor.authorIsmail, NMen_US
dc.contributor.authorOthman, Hen_US
dc.contributor.authorCozier, GEen_US
dc.contributor.authorAcharya, KRen_US
dc.contributor.authorIsaac, REen_US
dc.date.accessioned2024-05-29T03:25:14Z
dc.date.available2024-05-29T03:25:14Z
dc.date.issued2017
dc.description.abstractThe control of mosquitoes is threatened by the appearance of insecticide resistance and therefore new control chemicals are urgently required. Here we show that inhibitors of mosquito peptidyl dipeptidase, a peptidase related to mammalian angiotensin-converting enzyme (ACE), are insecticidal to larvae of the mosquitoes, Aedes aegypti and Anopheles gambiae. ACE inhibitors (captopril, fosinopril and fosinoprilat) and two peptides (trypsin-modulating oostatic factor/TMOF and a bradykinin-potentiating peptide, BPP-12b) were all inhibitors of the larval ACE activity of both mosquitoes. Two inhibitors, captopril and fosinopril (a pro-drug ester of fosinoprilat), were tested for larvicidal activity. Within 24 h captopril had killed > 90% of the early instars of both species with 3(rd) instars showing greater resistance. Mortality was also high within 24 h of exposure of 1(st), 2(nd) and 3(rd) instars of An. gambiae to fosinopril. Fosinopril was also toxic to Ae. aegypti larvae, although the 1st instars appeared to be less susceptible to this pro-drug even after 72 h exposure. Homology models of the larval An. gambiae ACE proteins (AnoACE2 and AnoACE3) reveal structural differences compared to human ACE, suggesting that structure-based drug design offers a fruitful approach to the development of selective inhibitors of mosquito ACE enzymes as novel larvicides.
dc.identifier.doi10.1038/srep45409
dc.identifier.issn2045-2322
dc.identifier.scopusWOS:000397541400001
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11916
dc.identifier.volume7
dc.languageEnglish
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reports
dc.sourceWeb Of Science (ISI)
dc.titleThe toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae
dc.typeArticleen_US
dspace.entity.typePublication

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