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A micro-computed tomography (micro-CT) analysis of postmenopausal osteoporotic rat models supplemented with ficus carica

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dc.FundingDetailsFaculty of Medicine, Nursing and Health Sciences, Monash University: USIM/FRGS/FPSK/32/50216 Ministry of Higher Education, Malaysia
dc.FundingDetailsThis study was supported by the Ministry of Higher Education (MoHE) Malaysia under Faculty of Medicine and Science Health, USIM (USIM/FRGS/FPSK/32/50216).
dc.citedby2
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Teknologi MARA (UiTM)
dc.contributor.authorMohammad A.en_US
dc.contributor.authorRazaly N.I.en_US
dc.contributor.authorRani M.D.M.en_US
dc.contributor.authorMuhammad Shamsir Mohd Arisen_US
dc.contributor.authorDom S.M.en_US
dc.contributor.authorEffendy N.M.en_US
dc.date.accessioned2024-05-28T08:24:56Z
dc.date.available2024-05-28T08:24:56Z
dc.date.issued2018
dc.description.abstractEstrogen replacement therapy (ERT) is known to be effective as an anti-osteoporotic treatment for postmenopausal women but exerted many adverse effects. Ficus carica (FC) or fig is a fruit rich in antioxidants and anti-inflammatory sources that are believed to contribute to its potential as ERT alternative. This study aimed to evaluate the effects of FC supplementation on the trabecular microarchitecture of postmenopausal osteoporotic rat models. Fifty-six adult female Sprague-Dawley rats were randomly divided into groups of Sham-operated (Sham), ovariectomized control (OVX), ovariectomized with 64.5 ?g/kg estrogen Premarin (ERT), ovariectomized with 50 mg/kg aqueous extract of FC (FC50), ovariectomized with 100 mg/kg aqueous extract of FC (FC100), ovariectomized with 50 mg/kg raw extract of FC (RAW50) and ovariectomized with 100 mg/kg raw extract of FC (RAW100). The treatments were given daily via oral gavage for eight weeks. After the treatment, rats were euthanized and femora were dissected out for micro-computed tomography (micro-CT) analysis. Trabecular structure of OVX femur showed significant osteoporotic deterioration in bone volume, trabecular separation, structural model index and connectivity density. ERT significantly reversed the osteoporotic-induced bone changes comparable to Sham level. RAW50 showed the best FC treatment in preserving bone microarchitecture. In conclusion, raw extraction of FC has high potential as an alternative against osteoporosis due to its high mineral contents and bioactive compounds.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.7324/JAPS.2018.8606
dc.identifier.epage45
dc.identifier.issn22313354
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85055442146
dc.identifier.spage39
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85055442146&doi=10.7324%2fJAPS.2018.8606&partnerID=40&md5=2b1e9e22ca77d35b4c9f394cec7a07b7
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8584
dc.identifier.volume8
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherOpen Science Publishers LLP Inc.en_US
dc.relation.ispartofOpen Accessen_US
dc.relation.ispartofJournal of Applied Pharmaceutical Science
dc.sourceScopus
dc.subjectBone microarchitectureen_US
dc.subjectEstrogenen_US
dc.subjectFicus caricaen_US
dc.subjectMicro-CTen_US
dc.subjectOvariectomyen_US
dc.subjectPostmenopausal osteoporosisen_US
dc.titleA micro-computed tomography (micro-CT) analysis of postmenopausal osteoporotic rat models supplemented with ficus caricaen_US
dc.title.alternativeJ. Appl. Pharm. Sci.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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